PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Benefits of Chronic Administration of a Carbohydrate-Free Diet on Biochemical and Morphometric Parameters in a Rat Model of Diet-Induced Metabolic Syndrome
Version 1
: Received: 14 June 2023 / Approved: 15 June 2023 / Online: 15 June 2023 (11:32:49 CEST)
How to cite:
Lares-Gutiérrez, D.A.; Galván-Valencia, M.; Flores-Baza, I.J.; Lazalde-Ramos, B.P. Benefits of Chronic Administration of a Carbohydrate-Free Diet on Biochemical and Morphometric Parameters in a Rat Model of Diet-Induced Metabolic Syndrome. Preprints2023, 2023061132. https://doi.org/10.20944/preprints202306.1132.v1
Lares-Gutiérrez, D.A.; Galván-Valencia, M.; Flores-Baza, I.J.; Lazalde-Ramos, B.P. Benefits of Chronic Administration of a Carbohydrate-Free Diet on Biochemical and Morphometric Parameters in a Rat Model of Diet-Induced Metabolic Syndrome. Preprints 2023, 2023061132. https://doi.org/10.20944/preprints202306.1132.v1
Lares-Gutiérrez, D.A.; Galván-Valencia, M.; Flores-Baza, I.J.; Lazalde-Ramos, B.P. Benefits of Chronic Administration of a Carbohydrate-Free Diet on Biochemical and Morphometric Parameters in a Rat Model of Diet-Induced Metabolic Syndrome. Preprints2023, 2023061132. https://doi.org/10.20944/preprints202306.1132.v1
APA Style
Lares-Gutiérrez, D.A., Galván-Valencia, M., Flores-Baza, I.J., & Lazalde-Ramos, B.P. (2023). Benefits of Chronic Administration of a Carbohydrate-Free Diet on Biochemical and Morphometric Parameters in a Rat Model of Diet-Induced Metabolic Syndrome. Preprints. https://doi.org/10.20944/preprints202306.1132.v1
Chicago/Turabian Style
Lares-Gutiérrez, D.A., Irene Jazmín Flores-Baza and Blanca Patricia Lazalde-Ramos. 2023 "Benefits of Chronic Administration of a Carbohydrate-Free Diet on Biochemical and Morphometric Parameters in a Rat Model of Diet-Induced Metabolic Syndrome" Preprints. https://doi.org/10.20944/preprints202306.1132.v1
Abstract
Diets that restrict the amount of carbohydrates positively affect markers related to metabolic syndrome (MS). However, completely carbohydrate-free diets have been studied in lesser extent, being their effect on biochemical and morphometric parameters in a rat model of MS the main objective of this study. MS was induced by a high-glucose diet for 20 weeks in male Wistar rats with a subsequent exposition to an essentially carbohydrate-free diet (CFD) for 20 weeks. Daily measurements of food consumption and monthly measurements of body weight were made. At week 40, glucose, insulin, lipid profile, ketone bodies, C-reactive protein (CRP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, liver and muscle glycogen, and serum, hepatic, renal and pancreatic malondialdehyde (MDA) were assessed. Exposition to CFD showed decrease in caloric intake and body weight. Likewise, the group showed normalization in liver and serum MDA parameters, insulin, lipid profile, ALT, liver glycogen, and creatinine. The CFD decreased glucose concentration and the inflammatory state, also, increased the concentration of ketone bodies and urea. The change towards CFD reverses the metabolic alterations generated with MS except for glycemia and uremia, probably due to the high rate of gluconeogenesis generated by the high protein content in the diet.
Keywords
carbohydrate-free diet; metabolic syndrome; biochemical parameters; morphometric parameters; rat model.
Subject
Public Health and Healthcare, Other
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
