Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Electrochemical Determination of Epinephrine in Pharmaceutical Preparation using Laponite Clay Modified Graphene Inkjet-Printed Electrode

Chancellin Nkepdep Pecheu
,
Victor Kougoum Tchieda
ORCID logo ,
Kevin Yemele Tajeu
ORCID logo ,
Sherman Lesly Zambou Jiokeng
ORCID logo ,
Andreas Lesch
ORCID logo ,
Ignas Kenfack Tonle
ORCID logo ,
Emmanuel Ngameni
,
Christoph Janiak
* ORCID logo
Version 1 : Received: 14 June 2023 / Approved: 15 June 2023 / Online: 15 June 2023 (09:55:14 CEST)

A peer-reviewed article of this Preprint also exists.

Pecheu, C.N.; Tchieda, V.K.; Tajeu, K.Y.; Jiokeng, S.L.Z.; Lesch, A.; Tonle, I.K.; Ngameni, E.; Janiak, C. Electrochemical Determination of Epinephrine in Pharmaceutical Preparation Using Laponite Clay-Modified Graphene Inkjet-Printed Electrode. Molecules 2023, 28, 5487. Pecheu, C.N.; Tchieda, V.K.; Tajeu, K.Y.; Jiokeng, S.L.Z.; Lesch, A.; Tonle, I.K.; Ngameni, E.; Janiak, C. Electrochemical Determination of Epinephrine in Pharmaceutical Preparation Using Laponite Clay-Modified Graphene Inkjet-Printed Electrode. Molecules 2023, 28, 5487.

Abstract

Epinephrine (EP, also called adrenaline) is a compound belonging to the catecholamine neurotransmitter family. It can cause neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. This work describes an amperometric sensor for the electroanalysis of EP, based on an inkjet-printed graphene electrode (IPGE), modified by a thin film of a laponite (La) clay mineral. The ion exchange properties and permeability of the prepared sensor (denoted La/IPGE) were evaluated using multi-sweep cyclic voltammetry while its charge transfer resistance was determined by electrochemical impedance spectroscopy. The results showed globally that La/IPGE exhibited more a sensitive response towards the detection of EP, in comparison with the bare IPGE. The developed sensor was directly applied for the determination of EP in aqueous solution using differential pulse voltammetry, and under optimized conditions, the calibration curve was plotted in the concentration range of 0.8 to 60 μM. The anodic peak current of EP was directly proportional to its concentration, leading to a detection limit of 0.29 μM. The sensor was successfully applied for the determination of EP in pharmaceutical preparation and best recovery rates were also obtained. The interfering effect of selected species was evaluated to highlight the selectivity of the elaborated sensor.

Keywords

Epinephrine; laponite; cyclic voltammetry; inkjet-printed graphene electrode

Subject

Chemistry and Materials Science, Analytical Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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