Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Shielding Burn Patients from Oxidative Stress: The Therapeutic Potential of Antioxidant Membranes

Herbert Leopold Haller
* ,
Frank Sander
,
Sebastian Philipp Nischwitz
,
Hanna Luze
ORCID logo ,
Dave Bandke
,
Matthias Rapp
,
Saskia Rapp
,
Bernd Hartmann
,
Mehmet Demircan
ORCID logo ,
Lars Peter Kamolz
ORCID logo
Version 1 : Received: 14 June 2023 / Approved: 14 June 2023 / Online: 14 June 2023 (15:32:50 CEST)

How to cite: Haller, H.L.; Sander, F.; Nischwitz, S.P.; Luze, H.; Bandke, D.; Rapp, M.; Rapp, S.; Hartmann, B.; Demircan, M.; Kamolz, L.P. Shielding Burn Patients from Oxidative Stress: The Therapeutic Potential of Antioxidant Membranes. Preprints 2023, 2023061065. https://doi.org/10.20944/preprints202306.1065.v1 Haller, H.L.; Sander, F.; Nischwitz, S.P.; Luze, H.; Bandke, D.; Rapp, M.; Rapp, S.; Hartmann, B.; Demircan, M.; Kamolz, L.P. Shielding Burn Patients from Oxidative Stress: The Therapeutic Potential of Antioxidant Membranes. Preprints 2023, 2023061065. https://doi.org/10.20944/preprints202306.1065.v1

Abstract

Although a slight imbalance between oxidative and antioxidative mediators is part of normal physiology that enables cell aging and the removal of dead cells, burns disturb this equilibrium locally and systemically. Topical burn dressings may attenuate local and systemic oxidative stress and positively influence the post-burn clinical course. This review integrated knowledge regarding the impact of burn dressings on oxidative stress. Using keywords and in-text searches, literature was identified from PubMed, Google Scholar, and Google articles, and studies on local or topical applications of wound dressings and associated oxidative stress were selected. As im-balances between oxidative mediators and antioxidative agents significantly contribute to organ dysfunction and healing disturbance, we investigated oxidative stress on organs, metabolic changes, clinical results, and oxidative parameters influenced by applied dressings. We found positive local and systemic effects of external burn dressings in laboratory and animal tests; however, such studies were rare in humans. Nevertheless, we identified successful cases of semi-occlusive, occlusive, and biologically active dressings that reduce oxidative stress in hu-man burns. In particular, we highlight promising clinical and laboratory results from lac-tate-releasing dressings. Our review provides an invaluable resource for future development and clinical applications of burn dressings.

Keywords

oxidative stress; dressing; lactate; polylactide; reactive oxygen species; wound healing

Subject

Medicine and Pharmacology, Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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