Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Autism spectrum disorder pathogenesis – a cross-sectional literature review

Agata Horecka-Lewitowicz
,
Olga Adamczyk-Gruszka
ORCID logo ,
Dorota Kozieł
ORCID logo ,
Hyebin Lim
,
Wojciech Lewitowicz
,
Piotr Lewitowicz
*
Version 1 : Received: 11 June 2023 / Approved: 13 June 2023 / Online: 13 June 2023 (16:51:45 CEST)

How to cite: Horecka-Lewitowicz, A.; Adamczyk-Gruszka, O.; Kozieł, D.; Lim, H.; Lewitowicz, W.; Lewitowicz, P. Autism spectrum disorder pathogenesis – a cross-sectional literature review. Preprints 2023, 2023060960. https://doi.org/10.20944/preprints202306.0960.v1 Horecka-Lewitowicz, A.; Adamczyk-Gruszka, O.; Kozieł, D.; Lim, H.; Lewitowicz, W.; Lewitowicz, P. Autism spectrum disorder pathogenesis – a cross-sectional literature review. Preprints 2023, 2023060960. https://doi.org/10.20944/preprints202306.0960.v1

Abstract

The etiology of autism spectrum disorder (ASD) has not yet been completely elucidated. Through time, multiple attempts have been made to uncover the causes of ASD. Different theories have been proposed, such as that it is caused by “Gods Wrath,” alternations in the gut–brain axis with an emphasis on gut dysbiosis, post vaccine complications, and genetic or even autoimmune causes. In this review we present data covering over 170 000 participants at age ranging from 2 to 14 years focusing on human cell changes rather than using animal models found in previous studies. The male/female ratio was 4:1. Data collection occurred in many countries covering ethnically diversified subjects. Moreover, we aim to show how the progress in genetic techniques influence the explanation found in medical White Papers based on the human genetic samples we have observed from our studies

Keywords

keyword ASD, autism, Asperger syndrome, molecular sequencing

Subject

Medicine and Pharmacology, Psychiatry and Mental Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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