PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Sex Differences In Glomerular Lesions, Atherosclerosis Progression, And In The Response To Angiotensin-Converting Enzyme Inhibitors In The Apoe-/- Mice Model
Version 1
: Received: 12 June 2023 / Approved: 13 June 2023 / Online: 13 June 2023 (03:22:47 CEST)
How to cite:
Mallén, A.; Rodriguez-Urquia, R.; Alvarez, R.; Dorca-Duch, E.; Navarro, E.; Hueso, M. Sex Differences In Glomerular Lesions, Atherosclerosis Progression, And In The Response To Angiotensin-Converting Enzyme Inhibitors In The Apoe-/- Mice Model. Preprints2023, 2023060867. https://doi.org/10.20944/preprints202306.0867.v1
Mallén, A.; Rodriguez-Urquia, R.; Alvarez, R.; Dorca-Duch, E.; Navarro, E.; Hueso, M. Sex Differences In Glomerular Lesions, Atherosclerosis Progression, And In The Response To Angiotensin-Converting Enzyme Inhibitors In The Apoe-/- Mice Model. Preprints 2023, 2023060867. https://doi.org/10.20944/preprints202306.0867.v1
Mallén, A.; Rodriguez-Urquia, R.; Alvarez, R.; Dorca-Duch, E.; Navarro, E.; Hueso, M. Sex Differences In Glomerular Lesions, Atherosclerosis Progression, And In The Response To Angiotensin-Converting Enzyme Inhibitors In The Apoe-/- Mice Model. Preprints2023, 2023060867. https://doi.org/10.20944/preprints202306.0867.v1
APA Style
Mallén, A., Rodriguez-Urquia, R., Alvarez, R., Dorca-Duch, E., Navarro, E., & Hueso, M. (2023). Sex Differences In Glomerular Lesions, Atherosclerosis Progression, And In The Response To Angiotensin-Converting Enzyme Inhibitors In The Apoe<sup>-/-</sup> Mice Model. Preprints. https://doi.org/10.20944/preprints202306.0867.v1
Chicago/Turabian Style
Mallén, A., Estanis Navarro and Miguel Hueso. 2023 "Sex Differences In Glomerular Lesions, Atherosclerosis Progression, And In The Response To Angiotensin-Converting Enzyme Inhibitors In The Apoe<sup>-/-</sup> Mice Model" Preprints. https://doi.org/10.20944/preprints202306.0867.v1
Abstract
Background: This study analyzes sex-based differences in renal structure and response to the Angiotensin-Converting Enzyme (ACE) inhibitor enalapril in a mouse model of atherosclerosis. Methods: ApoE-/- mice (8 weeks old) received enalapril (5 mg/kg/day, subcutaneous) or PBS as a control for an additional 14 weeks. Each group consisted of six males and six females. Results: Females exhibited elevated LDL-cholesterol levels, while males presented higher creatinine levels and proteinuria. Enalapril effectively reduced blood pressure in both groups, but proteinuria decreased significantly only in females. Plaque size analysis and assessment of kidney inflammation revealed no significant sex-based differences. However, males displayed more severe glomerular injury, with increased mesangial expansion, mesangiolysis, glomerular foam cells and activated parietal epithelial cells (PECs). Enalapril mitigated mesangial expansion, glomerular inflammation (particularly in females), and the hypertrophy of PECs in males. Conclusion: This study demonstrates sex-based differences in the response to enalapril in a mouse model of atherosclerosis. Males exhibited more severe glomerular injury, while enalapril provided renal protection, particularly in females. These findings suggest potential sex-specific considerations for ACE inhibitor therapy in chronic kidney disease and atherosclerosis cardiovascular disease. Further research is needed to elucidate the underlying mechanism behind these observations.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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