Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine

Lauretta Turin
* ORCID logo ,
Marina Michela Piccione
,
Fabio Crosa
,
Paola Dall'Ara
ORCID logo ,
Joel Filipe
ORCID logo ,
Laura Zarucco
ORCID logo
Version 1 : Received: 9 June 2023 / Approved: 12 June 2023 / Online: 12 June 2023 (05:23:03 CEST)

A peer-reviewed article of this Preprint also exists.

Turin, L.; Piccione, M.M.; Crosa, F.; Dall’Ara, P.; Filipe, J.; Zarucco, L. Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine. Vet. Sci. 2023, 10, 460. Turin, L.; Piccione, M.M.; Crosa, F.; Dall’Ara, P.; Filipe, J.; Zarucco, L. Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine. Vet. Sci. 2023, 10, 460.

Abstract

Botulinum neurotoxins (BoNTs) are emerging as multipurpose therapeutic compounds for the treatment of several different syndromes involving peripheral and central nervous systems, and muscular and musculoskeletal disorders both in human and veterinary medicine. Therefore, the studies of BoNTs are rapidly developing and identifying newly produced BoNT variants. Efforts should be made to clarify the biological and pharmacological characteristics of these novel BoNTs as well as the natural ones. The high potential of BoNTs as a therapeutic compound for medical syndromes lies on its ability to reach a specific cell type bypassing other cells, thus having mild or no side effects. In this paper the recent developments on BoNTs are reviewed with the aim to analyze the current knowledge on BoNTs biological mechanisms of action, immunogenicity, formulations, and therapeutic applications in the veterinary field, highlighting advantages and drawbacks and identifying the gaps to be filled in order to address research priorities.

Keywords

Clostridium botulinum; botulism; neurotoxin; BoNT; therapeutic; antibodies; horse; dog; cat; farm animals

Subject

Medicine and Pharmacology, Veterinary Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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