Roux-En-Y Gastric Bypass Improves Adiponectin to Leptin Ratio and Inflammatory Profile in Severely Obese Women With and Without Metabolic Syndrome: A Randomized Controlled Trial

Sandra M.B.P. Moreira; Andre L. L. Bachi; Elias I. Jirjos; Carlos A. Malheiros; Sergio Vencio; Vera Lúcia dos Santos Alves; Alan R. T. Sousa; Lucenda A. Felipe; Eduardo A. Perez; Maria E. M. Lino; Shayra K. A. Souza; Juliana M. B. Santos; Miriã C. Oliveira; Adriano Luís Fonseca; Carlos H. M. Silva; Rodolfo P Vieira; Giuseppe Insalaco; Wilson R. Freitas Júnior; Luis V. F. Oliveira

doi:10.20944/preprints202306.0633.v1

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preprints.org > public health and healthcare > primary health care > doi: 10.20944/preprints202306.0633.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Roux-En-Y Gastric Bypass Improves Adiponectin to Leptin Ratio and Inflammatory Profile in Severely Obese Women With and Without Metabolic Syndrome: A Randomized Controlled Trial

Sandra M.B.P. Moreira

Vera Lúcia dos Santos Alves

Wilson R. Freitas Júnior

Luis V. F. Oliveira

Version 1 : Received: 7 June 2023 / Approved: 8 June 2023 / Online: 8 June 2023 (10:47:49 CEST)

A peer-reviewed article of this Preprint also exists.

Moreira, S.M.B.P.; Bachi, A.L.L.; Jirjos, E.I.; Malheiros, C.A.; Vencio, S.; Alves, V.L.S.; Sousa, A.R.T.; Felipe, L.A.; Perez, E.A.; Lino, M.E.M.; Souza, S.K.A.; Santos, J.M.B.; Oliveira, M.C.; Fonseca, A.L.; Silva, C.H.M.; Vieira, R.P.; Insalaco, G.; Freitas Júnior, W.R.; Oliveira, L.V.F. Roux-en-Y Gastric Bypass Improves Adiponectin to Leptin Ratio and Inflammatory Profile in Severely Obese Women with and without Metabolic Syndrome: A Randomized Controlled Trial. Nutrients 2023, 15, 3312. Moreira, S.M.B.P.; Bachi, A.L.L.; Jirjos, E.I.; Malheiros, C.A.; Vencio, S.; Alves, V.L.S.; Sousa, A.R.T.; Felipe, L.A.; Perez, E.A.; Lino, M.E.M.; Souza, S.K.A.; Santos, J.M.B.; Oliveira, M.C.; Fonseca, A.L.; Silva, C.H.M.; Vieira, R.P.; Insalaco, G.; Freitas Júnior, W.R.; Oliveira, L.V.F. Roux-en-Y Gastric Bypass Improves Adiponectin to Leptin Ratio and Inflammatory Profile in Severely Obese Women with and without Metabolic Syndrome: A Randomized Controlled Trial. Nutrients 2023, 15, 3312.

Abstract

Obesity is a troubling public health problem worldwide as it increases risks of respiratory complications, systemic arterial hypertension, type 2 diabetes mellitus, sleep disorders, cardiovascular diseases, and metabolic syndrome (MetS). As a measure to counteract comorbidities associated with severe obesity, bariatric surgery stands out. This study aimed to investigate the adiponectin/leptin ratio in women with severe obesity with and without MetS undergone Roux-en-Y Gastric Bypass (RYGB) and to characterize the biochemical, glucose, and inflammatory parameters of blood in women with severe obesity before and after RYGB. Were enrolled female with severe obesity undergoing RYGP with MetS (n=11) and without (n=39). Anthropometric data and blood samples were obtained before and 6 months after RYGB to analyze total cholesterol, low-density lipoprotein (LDL), high- density lipoprotein (HDL), non-HDL total cholesterol, and glucose; and circulating levels of adiponectin and leptin. Significant reductions in weight, body mass index, and glucose, total cholesterol, LDL, and leptin were observed after surgery, with higher levels of HDL, adiponectin, and adiponectin/leptin ratio observed after surgery compared to preoperative values. This study demonstrated that weight loss induced by RYGB in patients with severe obesity with or without MetS improved biochemical and systemic inflammatory parameters, particularly the adiponectin/leptin ratio.

Keywords

Roux-en-Y Gastric Bypass; Adiponectin to leptin ratio; Inflammatory profile; Severely obese; Metabolic syndrome

Subject

Public Health and Healthcare, Primary Health Care

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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