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Roux-En-Y Gastric Bypass Improves Adiponectin to Leptin Ratio and Inflammatory Profile in Severely Obese Women With and Without Metabolic Syndrome: A Randomized Controlled Trial
Moreira, S.M.B.P.; Bachi, A.L.L.; Jirjos, E.I.; Malheiros, C.A.; Vencio, S.; Alves, V.L.S.; Sousa, A.R.T.; Felipe, L.A.; Perez, E.A.; Lino, M.E.M.; Souza, S.K.A.; Santos, J.M.B.; Oliveira, M.C.; Fonseca, A.L.; Silva, C.H.M.; Vieira, R.P.; Insalaco, G.; Freitas Júnior, W.R.; Oliveira, L.V.F. Roux-en-Y Gastric Bypass Improves Adiponectin to Leptin Ratio and Inflammatory Profile in Severely Obese Women with and without Metabolic Syndrome: A Randomized Controlled Trial. Nutrients2023, 15, 3312.
Moreira, S.M.B.P.; Bachi, A.L.L.; Jirjos, E.I.; Malheiros, C.A.; Vencio, S.; Alves, V.L.S.; Sousa, A.R.T.; Felipe, L.A.; Perez, E.A.; Lino, M.E.M.; Souza, S.K.A.; Santos, J.M.B.; Oliveira, M.C.; Fonseca, A.L.; Silva, C.H.M.; Vieira, R.P.; Insalaco, G.; Freitas Júnior, W.R.; Oliveira, L.V.F. Roux-en-Y Gastric Bypass Improves Adiponectin to Leptin Ratio and Inflammatory Profile in Severely Obese Women with and without Metabolic Syndrome: A Randomized Controlled Trial. Nutrients 2023, 15, 3312.
Moreira, S.M.B.P.; Bachi, A.L.L.; Jirjos, E.I.; Malheiros, C.A.; Vencio, S.; Alves, V.L.S.; Sousa, A.R.T.; Felipe, L.A.; Perez, E.A.; Lino, M.E.M.; Souza, S.K.A.; Santos, J.M.B.; Oliveira, M.C.; Fonseca, A.L.; Silva, C.H.M.; Vieira, R.P.; Insalaco, G.; Freitas Júnior, W.R.; Oliveira, L.V.F. Roux-en-Y Gastric Bypass Improves Adiponectin to Leptin Ratio and Inflammatory Profile in Severely Obese Women with and without Metabolic Syndrome: A Randomized Controlled Trial. Nutrients2023, 15, 3312.
Moreira, S.M.B.P.; Bachi, A.L.L.; Jirjos, E.I.; Malheiros, C.A.; Vencio, S.; Alves, V.L.S.; Sousa, A.R.T.; Felipe, L.A.; Perez, E.A.; Lino, M.E.M.; Souza, S.K.A.; Santos, J.M.B.; Oliveira, M.C.; Fonseca, A.L.; Silva, C.H.M.; Vieira, R.P.; Insalaco, G.; Freitas Júnior, W.R.; Oliveira, L.V.F. Roux-en-Y Gastric Bypass Improves Adiponectin to Leptin Ratio and Inflammatory Profile in Severely Obese Women with and without Metabolic Syndrome: A Randomized Controlled Trial. Nutrients 2023, 15, 3312.
Abstract
Obesity is a troubling public health problem worldwide as it increases risks of respiratory complications, systemic arterial hypertension, type 2 diabetes mellitus, sleep disorders, cardiovascular diseases, and metabolic syndrome (MetS). As a measure to counteract comorbidities associated with severe obesity, bariatric surgery stands out. This study aimed to investigate the adiponectin/leptin ratio in women with severe obesity with and without MetS undergone Roux-en-Y Gastric Bypass (RYGB) and to characterize the biochemical, glucose, and inflammatory parameters of blood in women with severe obesity before and after RYGB. Were enrolled female with severe obesity undergoing RYGP with MetS (n=11) and without (n=39). Anthropometric data and blood samples were obtained before and 6 months after RYGB to analyze total cholesterol, low-density lipoprotein (LDL), high- density lipoprotein (HDL), non-HDL total cholesterol, and glucose; and circulating levels of adiponectin and leptin. Significant reductions in weight, body mass index, and glucose, total cholesterol, LDL, and leptin were observed after surgery, with higher levels of HDL, adiponectin, and adiponectin/leptin ratio observed after surgery compared to preoperative values. This study demonstrated that weight loss induced by RYGB in patients with severe obesity with or without MetS improved biochemical and systemic inflammatory parameters, particularly the adiponectin/leptin ratio.
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