Taslamacioglu Duman, T.; Ozkul, F.N.; Balci, B. Could Systemic Inflammatory Index Predict Diabetic Kidney Injury in Type 2 Diabetes Mellitus? Diagnostics2023, 13, 2063.
Taslamacioglu Duman, T.; Ozkul, F.N.; Balci, B. Could Systemic Inflammatory Index Predict Diabetic Kidney Injury in Type 2 Diabetes Mellitus? Diagnostics 2023, 13, 2063.
Taslamacioglu Duman, T.; Ozkul, F.N.; Balci, B. Could Systemic Inflammatory Index Predict Diabetic Kidney Injury in Type 2 Diabetes Mellitus? Diagnostics2023, 13, 2063.
Taslamacioglu Duman, T.; Ozkul, F.N.; Balci, B. Could Systemic Inflammatory Index Predict Diabetic Kidney Injury in Type 2 Diabetes Mellitus? Diagnostics 2023, 13, 2063.
Abstract
Background: The systemic inflammatory index (SII) is a new inflammatory marker that has been the subject of various studies in diseases with chronic inflammation. Diabetic nephropathy is also a disease that goes with chronic inflammation. We aimed to evaluate the relationship be-tween SII and diabetic nephropathy.
Methods: Patients with diabetes who applied to our outpatient clinic are included in the study. Diabetic patients are divided into two groups: those with diabetic nephropathy and those with-out. In addition, healthy individuals who applied to our clinic for general check-ups during these dates are included as control group. The SII values and other characteristics of the three study groups are compared.
Results: The median SII value for those with DKI was 584 (178-4819); for those without DKI, it was 282 (64-618); and for the control group, it was 236 (77.5-617) (p<0.001). SII was significantly and positively correlated with BMI, weight, blood glucose, HbA1c, CRP and creatinine, and neg-atively correlated with glomerular filtration rate (GFR) value. The SII value higher than 336 has 75% sensitivity and 70% specificity in detecting DKI.
Conclusion: The SII value could predict diabetic kidney injury in diabetics and it could be used as an adjunctive diagnostic tool.
Keywords
diabetic kidney injury; inflammation; systemic inflammatory index
Subject
Medicine and Pharmacology, Internal Medicine
Copyright:
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