Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Effectiveness and Safety of Glucosamine in Osteoarthritis: A Literature Review

Nam Xuan Vo
* ORCID logo ,
Ngan Nguyen Hoang Le
,
Trinh Dang Phuong Chu
,
Huong Lai Pham
,
Khang Xuan An Dinh
,
Uyen Thi Thuc Che
,
Thanh Thi Thanh Ngo
,
Tien Thuy Bui
Version 1 : Received: 6 June 2023 / Approved: 7 June 2023 / Online: 7 June 2023 (07:58:49 CEST)
Version 2 : Received: 7 June 2023 / Approved: 7 June 2023 / Online: 7 June 2023 (10:08:22 CEST)

A peer-reviewed article of this Preprint also exists.

Vo, N.X.; Le, N.N.H.; Chu, T.D.P.; Pham, H.L.; Dinh, K.X.A.; Che, U.T.T.; Ngo, T.T.T.; Bui, T.T. Effectiveness and Safety of Glucosamine in Osteoarthritis: A Systematic Review. Pharmacy 2023, 11, 117. Vo, N.X.; Le, N.N.H.; Chu, T.D.P.; Pham, H.L.; Dinh, K.X.A.; Che, U.T.T.; Ngo, T.T.T.; Bui, T.T. Effectiveness and Safety of Glucosamine in Osteoarthritis: A Systematic Review. Pharmacy 2023, 11, 117.

Abstract

Knee osteoarthritis is the most popular type of osteoarthritis that causes extreme pain in elderly. Currently there is no cure for osteoarthritis. To lessen clinical symptoms, glucosamine was suggested. The primary goal of our study is to evaluate the efficacy and safety of glucosamine from recent studies. Electronic databases such as PubMed, Scopus, Cochrane were used to assess RCT. From the beginning through March 2023, the papers were checked, and if they fulfilled the inclusion criteria, they were then examined. WOMAC and VAS scales were considered as main outcome measure. A total of 15 studies were selected. Global pain was significantly decreased in comparison to placebo, as measured by the VAS index, with an overall effect size SMD of -7.41 ([95% CI] 14.31, 0.51). The WOMAC scale confirmed that pain, stiffness, and physical function had improved, however the effects were insufficient. A statistical update also revealed that there were no reports of serious medication interactions or significant adverse events. To summarize, glucosamine is more effective than a placebo at reducing pain in knee osteoarthritis patients. In long-term treatment, oral glucosamine sulfate 1500 mg/day is believed to be well tolerated.

Keywords

Osteoarthritis; Effectiveness; Safety; Glucosamine; systematic review

Subject

Medicine and Pharmacology, Pharmacy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (1)

Comment 1
Received: 7 June 2023
Commenter: Nam Vo
Commenter's Conflict of Interests: Author
Comment: Some format errors by preprints checking before were updated.
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