Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Diagnostic Role of Native T1 mapping Compared to Conventional Magnetic Resonance Techniques in Cardiac Disease in a Real-life Cohort

Giovanni Donato Aquaro
* ORCID logo ,
Silvia Monastero
,
Giancarlo Todiere
,
Andrea Barison
,
Carmelo De Gori
ORCID logo ,
Crysanthos Grigoratos
,
Maria Luisa Parisella
,
Lorenzo Faggioni
,
Dania Cioni
,
Riccardo Lencioni
,
Emanuele Neri
ORCID logo
Version 1 : Received: 6 June 2023 / Approved: 6 June 2023 / Online: 6 June 2023 (14:48:58 CEST)

A peer-reviewed article of this Preprint also exists.

Aquaro, G.D.; Monastero, S.; Todiere, G.; Barison, A.; De Gori, C.; Grigoratos, C.; Parisella, M.L.; Faggioni, L.; Cioni, D.; Lencioni, R.; Neri, E. Diagnostic Role of Native T1 Mapping Compared to Conventional Magnetic Resonance Techniques in Cardiac Disease in a Real-Life Cohort. Diagnostics 2023, 13, 2461. Aquaro, G.D.; Monastero, S.; Todiere, G.; Barison, A.; De Gori, C.; Grigoratos, C.; Parisella, M.L.; Faggioni, L.; Cioni, D.; Lencioni, R.; Neri, E. Diagnostic Role of Native T1 Mapping Compared to Conventional Magnetic Resonance Techniques in Cardiac Disease in a Real-Life Cohort. Diagnostics 2023, 13, 2461.

Abstract

We sought to compare native T1 mapping to conventional Late gadolinium enhancement (LGE) and T2-STIR techniques in a cohort of consecutive patients undergoing cardiac MRI (CMR).. CMR was performed in 323 patients, 206 males (64%), mean age 54±8 years and in 27 age- and sex- matched healthy controls. At T2-STIR images myocardial hyperintensity suggesting edema was found in 41 patients (27%). LGE images were positive in 206 patients (64%). T1 mapping was abnormal in 171 (49%). In 206 patients (64%) a matching between LGE and native T1 was found. T1 was abnormal in 32 out of 41 (78%) with edema at T2-STIR. Overall, LGE and/or T2-STIR were abnormal in 209 patients, whereas native T1 in 154(52%). Conventional techniques and T1 mapping were concordant in 208 patients (64%). In 39 patients T1 mapping was positive despite negative conventional techniques (12%). T1 mapping was able in conditions with diffuse myocardial damage as cardiac amyloidosis, scleroderma and Fabry disease (additive role in 42%). On contrast, T1 mapping was less effective in cardiac disease with regional distribution of myocardial damage as myocardial infarction, HCM, myocarditis. In conclusion, conventional LGE/T2-STIR and T1 mapping are complementary techniques and should be used together in every CMR examination.

Keywords

cardiac magnetic resonance; T1 mapping; Late gadolinium enhancement; T2-STIR

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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