Review
Version 1
Preserved in Portico This version is not peer-reviewed
Physiological Calcium Phosphate Management in Two Biofluids
Version 1
: Received: 2 June 2023 / Approved: 6 June 2023 / Online: 6 June 2023 (14:19:16 CEST)
How to cite: Nelson, D. Physiological Calcium Phosphate Management in Two Biofluids. Preprints 2023, 2023060464. https://doi.org/10.20944/preprints202306.0464.v1 Nelson, D. Physiological Calcium Phosphate Management in Two Biofluids. Preprints 2023, 2023060464. https://doi.org/10.20944/preprints202306.0464.v1
Abstract
Management of calcium and phosphate in biofluids is key to maintaining physiological mineral homeostasis (i.e., appropriate mineralization of hard tissues and an absence of mineral deposition in soft tissues). This review describes and contrasts the ways vertebrates manage calcium phosphate in two biological fluids (breast milk and serum) and illustrates the benefits of mineral sequestration by proteins. In milk, phosphoprotein-sequestered calcium magnesium phosphates provide nutritional support, whereas in serum, protein-sequestered calcium phosphates control transport and delivery of calcium and phosphate to tissues for biological function or excretion. In addition, subsets of sequestered phosphates in serum have been identified as culprits underlying ectopic deposition of calcium phosphates and toxicity.
Keywords
Calcium phosphate; calciprotein particles; nanoclusters; intrinsically disordered proteins; crystal toxicity; milk; serum
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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