Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical and Pathological Features of Osteosarcomas of the Jaws. A Retrospective Study

Jesus Rodriguez-Molinero
ORCID logo ,
Jose Juan Pozo-Kreilinger
,
Juan-Antonio Ruiz-Roca
* ,
Antonio Francisco López-Sánchez
* ORCID logo ,
Jose Luis Cebrian-Carretero
ORCID logo
Version 1 : Received: 31 May 2023 / Approved: 1 June 2023 / Online: 1 June 2023 (08:49:20 CEST)

A peer-reviewed article of this Preprint also exists.

Rodriguez-Molinero, J.; Pozo-Kreilinger, J.J.; Ruiz-Roca, J.A.; Lopez-Sanchez, A.F.; Cebrian-Carretero, J.L. Clinical and Pathological Features of Osteosarcomas of the Jaws: A Retrospective Study. Clinics and Practice 2024, 14, 965–979, doi:10.3390/clinpract14030077. Rodriguez-Molinero, J.; Pozo-Kreilinger, J.J.; Ruiz-Roca, J.A.; Lopez-Sanchez, A.F.; Cebrian-Carretero, J.L. Clinical and Pathological Features of Osteosarcomas of the Jaws: A Retrospective Study. Clinics and Practice 2024, 14, 965–979, doi:10.3390/clinpract14030077.

Abstract

Introduction: Osteosarcomas of the jaw (OSJ) are rare tumors with a different behavior from osteosarcomas of other bones. This study aims to analyze the clinical, pathological, and therapeutic characteristics of this type of sarcoma. Methods: a retrospective observational study of cases diagnosed with OSJ registered at the “La Paz” University Hospital (Madrid). Results: Eight cases with a diagnosis of OSJ were obtained in a study period of 22 years (2000-2022). The mean age was 41 years. The distribution was 1:1 between the maxilla and mandible. Painful inflammation was the most frequent clinical manifestation. Conventional osteoblastic osteosarcoma was the most common. Survival at 5 years was 50%, while at 10 years, it decreased to 25%. Conclusions: OSJ differs from conventional osteosarcomas of long tubular bones. Surgery continues to be the mainstay of treatment; more studies are needed in which more standardized protocols can be proposed for adjuvant therapeutic management.

Keywords

osteosarcoma of the jaws; head and neck cancer; oral cancer; malignant bone tumor

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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