Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

MicroRNA-Related Polymorphism and Their Association With Fibromyalgia

Fabian Berg
,
Dirk Alexander Moser
* ORCID logo ,
Verena Hagena
,
Fabian Streit
ORCID logo ,
Benjamin Mosch
,
Robert Kumsta
,
Stephan Herpertz
,
Martin Diers
ORCID logo
Version 1 : Received: 30 May 2023 / Approved: 1 June 2023 / Online: 1 June 2023 (04:50:50 CEST)

A peer-reviewed article of this Preprint also exists.

Berg, F.; Moser, D.A.; Hagena, V.; Streit, F.; Mosch, B.; Kumsta, R.; Herpertz, S.; Diers, M. MicroRNA-Related Polymorphism and Their Association with Fibromyalgia. Genes 2023, 14, 1312. Berg, F.; Moser, D.A.; Hagena, V.; Streit, F.; Mosch, B.; Kumsta, R.; Herpertz, S.; Diers, M. MicroRNA-Related Polymorphism and Their Association with Fibromyalgia. Genes 2023, 14, 1312.

Abstract

MicroRNAs are tissue-specifically expressed short RNAs that serve post-transcriptional gene reg-ulation. A specific microRNA can bind to mRNAs of different genes and thereby suppress their protein production. In the context of the complex phenotype of fibromyalgia, we used the Axiom miRNA Target Site Genotyping Array to search genome-wide for DNA variations in microRNA genes, their regulatory regions and in the 3'UTR of protein-coding genes. To identify dis-ease-relevant DNA polymorphisms, a cohort of 176 female fibromyalgia patients was studied in comparison to a cohort of 162 healthy women. The association between 48.329 markers and fibromyalgia was investigated using logistic regression adjusted for population stratification. 29 markers had p-values < 1 × 10-3 and the strongest asso-ciation was observed for rs758459 (p-value of 0.0001), located in the Neurogenin 1 gene, targeted by hsa-miR-130a-3p. Furthermore, we identified a gene locus (rs2295963) predicted to disrupt binding of hsa-miR-1-3p. Both microRNAs were previously reported to be differentially expressed in fi-bromyalgia patients. Despite its limited statistical power, this study reports two microRNA-related polymorphisms which may play a functional role in the pathogenesis of fibromyalgia. For a better understanding of the disease pattern, further functional analyses on the biological significance of microRNAs and microRNA-related polymorphisms are required.

Keywords

Fibromyalgia (FM); miRNA; pleiotropy; gene regulation; epigenetics

Subject

Biology and Life Sciences, Behavioral Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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