Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Serum Biomarker Concentrations on Admission in Acute Traumatic Brain Injury: Associations with, TBI Severity, Toxoplasma gondii Infection and Outcome in a Referral Hospital Setting, Cameroon

Franklin Chu Buh
* ORCID logo ,
Germaine Sotoing Taiwe
ORCID logo ,
Firas H. Kobeissy
ORCID logo ,
Kevin W. Wang
ORCID logo ,
Andrew I.R. Maas
ORCID logo ,
Basil Kum Meh
,
Motah Mathieu
,
Eric Youm
,
Peter J.A. Hutchinson
,
Irene Ule Ngole Sumbele
Version 1 : Received: 25 May 2023 / Approved: 26 May 2023 / Online: 26 May 2023 (10:28:07 CEST)

A peer-reviewed article of this Preprint also exists.

Buh, F.C.; Taiwe, G.S.; Kobeissy, F.H.; Wang, K.W.; Maas, A.I.R.; Motah, M.; Meh, B.K.; Youm, E.; Hutchinson, P.J.A.; Sumbele, I.U.N. Serum Biomarker Concentrations upon Admission in Acute Traumatic Brain Injury: Associations with TBI Severity, Toxoplasma gondii Infection, and Outcome in a Referral Hospital Setting in Cameroon. NeuroSci 2023, 4, 164-177. Buh, F.C.; Taiwe, G.S.; Kobeissy, F.H.; Wang, K.W.; Maas, A.I.R.; Motah, M.; Meh, B.K.; Youm, E.; Hutchinson, P.J.A.; Sumbele, I.U.N. Serum Biomarker Concentrations upon Admission in Acute Traumatic Brain Injury: Associations with TBI Severity, Toxoplasma gondii Infection, and Outcome in a Referral Hospital Setting in Cameroon. NeuroSci 2023, 4, 164-177.

Abstract

Despite the available literature on traumatic brain injury (TBI) biomarkers elsewhere, data are limited or non-existent in sub-Saharan Africa (SSA). The aim of the study was to analyse associations in acute TBI between admission serum biomarker concentrations and TBI severity, CT-scan findings and outcome as well as explore the influence of concurrent Toxoplasma gondii infection. Concentrations of serum biomarkers (GFAP, NFL Tau, UCH-L1, and S100B) were measured and Toxoplasma gondii detected in samples obtained <24 hours post-injury. The GOSE was used to evaluate 6 months outcome. All biomarkers levels increased with severity of TBI, but this increase was significant only for NFL (P=0.01). GFAP values significantly increased (P=0.026) in those with unfavorable outcome. Tau levels were higher in those who died (P=0.017). GFAP and NFL were sensitive to CT-scan pathology (p values respectively 0.004 and 0.002). S100B levels were higher (P<0.001) in TBI patients seropositive to Toxoplasma gondii. NFL was found to be sensitive to TBI severity while NFL and GFAP were predictive of CT intracranial abnormalities. Increased levels of GFAP and Tau were associated with poorer outcomes 6 months after TBI. S100B levels were significantly higher in T. gondii seropositive TBI patients.

Keywords

Serum biomarkers; Traumatic brain injury; CT-scan findings; outcome; Toxoplasma gondii

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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