Version 1
: Received: 23 May 2023 / Approved: 24 May 2023 / Online: 24 May 2023 (04:37:56 CEST)
How to cite:
Savchuk, T.; Grinvald, Y.; Ali, M.; Sepetiene, R.; Saussakova, S.; Zhagazieva, K.; Imashpayev, D.; Abdrakhmanova, S. Association of Positive Hepatitis B Serology Markers With Risk and Behavior Factors in Kazakhstan Blood Donors: A Cross Sectional Study. Preprints2023, 2023051690. https://doi.org/10.20944/preprints202305.1690.v1
Savchuk, T.; Grinvald, Y.; Ali, M.; Sepetiene, R.; Saussakova, S.; Zhagazieva, K.; Imashpayev, D.; Abdrakhmanova, S. Association of Positive Hepatitis B Serology Markers With Risk and Behavior Factors in Kazakhstan Blood Donors: A Cross Sectional Study. Preprints 2023, 2023051690. https://doi.org/10.20944/preprints202305.1690.v1
Savchuk, T.; Grinvald, Y.; Ali, M.; Sepetiene, R.; Saussakova, S.; Zhagazieva, K.; Imashpayev, D.; Abdrakhmanova, S. Association of Positive Hepatitis B Serology Markers With Risk and Behavior Factors in Kazakhstan Blood Donors: A Cross Sectional Study. Preprints2023, 2023051690. https://doi.org/10.20944/preprints202305.1690.v1
APA Style
Savchuk, T., Grinvald, Y., Ali, M., Sepetiene, R., Saussakova, S., Zhagazieva, K., Imashpayev, D., & Abdrakhmanova, S. (2023). Association of Positive Hepatitis B Serology Markers With Risk and Behavior Factors in Kazakhstan Blood Donors: A Cross Sectional Study. Preprints. https://doi.org/10.20944/preprints202305.1690.v1
Chicago/Turabian Style
Savchuk, T., Dulat Imashpayev and Saniya Abdrakhmanova. 2023 "Association of Positive Hepatitis B Serology Markers With Risk and Behavior Factors in Kazakhstan Blood Donors: A Cross Sectional Study" Preprints. https://doi.org/10.20944/preprints202305.1690.v1
Abstract
Background and Aim. Recently made analysis for anti-HBcor prevalence within Kazakhstan blood donors population concluded 17.2% rate. Considering these data are among the highest of infectivity results worldwide, an objective of this study was to define an association of positive Hepatitis B serology markers with risk and behavior factors.
Methods. The blood donors’ samples were tested for anti-HBcore total (IgG/IgM) and anti-HBs, by CLIA on the Architect i2000SR platform (Abbott). Surrogate alanine transferase (ALT) markers for all blood donors were tested by kinetic method on the Biosystems A25 analyzer. A questionnaire was developed for socio-demographic characteristics, donors’ nutrition habits, cholesterol levels and history of smoking, alcohol consumption. Informed consent was obtained from all study participants. Statistics was calculated using the R software program (version 4.1.1, USA, 2021).
Results. A group of 5709 blood donors participated in the study. Participants with positive anti-HBcore scores were on average older (41.8 vs 34.4 years, p<0.001), Kazakh (88.7% vs 83.0%, p<0.001), married (74.0% vs 55.6%, p<0.001), had a secondary education (70.1% vs. 59.4%, p=0.03), smoked (27.9% vs. 24.3%, p=0.05), had a longer smoking history (13.6±9.5 years vs. 9.8±8.5 years, p<0.001), and various hypercholestesterolaemia (6.2% vs 3.9%, p=0.02). Predominantly their main meal was dinner (17.0% vs 14.2%, p=0.03).
Analysis for associations of socio-demographics characteristics, risk factors, nutrition with anti-HBs, showed that those who have secondary education level (70.1%) were more likely to be anti-HBs-positive (p=0.03). No other significant correlations for anti-HBs were observed.
Conclusions. The risk factors and behavior analysis highlighted the blood donors’ overall health status. Positive Hepatitis B markers associated with statistically significant characteristics from socio-demography, nutrition habits or risk factors could support further pathogenesis studies looking for HBV treatment guides fulfilling the existing gaps.
Keywords
hepatitis B; anti HBcore; risk factors; blood donors
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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