Version 1
: Received: 22 May 2023 / Approved: 23 May 2023 / Online: 23 May 2023 (07:43:32 CEST)
How to cite:
Ting, M.; Neiva, R.; Tafline, L.; Suzuki, J.B. The Bidirectional Association Between Periodontitis and COVID-19: A Review of Current Evidence. Preprints.org2023, 2023051601. https://doi.org/10.20944/preprints202305.1601.v1
Ting, M.; Neiva, R.; Tafline, L.; Suzuki, J.B. The Bidirectional Association Between Periodontitis and COVID-19: A Review of Current Evidence. Preprints.org 2023, 2023051601. https://doi.org/10.20944/preprints202305.1601.v1
Cite as:
Ting, M.; Neiva, R.; Tafline, L.; Suzuki, J.B. The Bidirectional Association Between Periodontitis and COVID-19: A Review of Current Evidence. Preprints.org2023, 2023051601. https://doi.org/10.20944/preprints202305.1601.v1
Ting, M.; Neiva, R.; Tafline, L.; Suzuki, J.B. The Bidirectional Association Between Periodontitis and COVID-19: A Review of Current Evidence. Preprints.org 2023, 2023051601. https://doi.org/10.20944/preprints202305.1601.v1
Abstract
The COVID-19 pandemic has brought marked changes worldwide to the management of airborne infectious diseases. It sparked the development of the SARS-CoV-2 vaccine and pharmacotherapeutics to prevent infection and increase the survival rate during the acute viral phase and the comorbidities associated with COVID-19. Periodontal disease may increase the morbidity and perhaps the mortality of a COVID-19 infection. However, the molecular interaction between periodontitis and COVID-19 infection remains undetermined. A potential pathogenic co-morbidity may involve periodontal pathogenic release of destructive cytokines in the highly inflamed connective tissue and risk for COVID-19. Additional biomarkers such as C-reactive proteins appear to play a role for risk and pathogenesis of COVID-19. The potential of herpesviruses, especially as it is related to aggressive periodontitis may also be a comorbidity for COVID-19. This paper reviews available evidence on the bidirectional association between periodontitis and COVID-19.
Medicine and Pharmacology, Dentistry and Oral Surgery
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
