Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Chitosan-Based Biomaterials for Hemostatic Applications: A Review on Recent Advances

Daniela Gheorghita
,
Horatiu Moldovan
ORCID logo ,
Alina Robu
,
Ana-Iulia Bita
,
Elena Grosu
,
Aurora Antoniac
,
Iuliana Corneschi
,
Iulian Antoniac
* ORCID logo ,
Alin Danut Bodog
* ORCID logo ,
Ciprian Ionut Bacila
ORCID logo
Version 1 : Received: 19 May 2023 / Approved: 22 May 2023 / Online: 22 May 2023 (10:51:01 CEST)

A peer-reviewed article of this Preprint also exists.

Gheorghiță, D.; Moldovan, H.; Robu, A.; Bița, A.-I.; Grosu, E.; Antoniac, A.; Corneschi, I.; Antoniac, I.; Bodog, A.D.; Băcilă, C.I. Chitosan-Based Biomaterials for Hemostatic Applications: A Review of Recent Advances. Int. J. Mol. Sci. 2023, 24, 10540. Gheorghiță, D.; Moldovan, H.; Robu, A.; Bița, A.-I.; Grosu, E.; Antoniac, A.; Corneschi, I.; Antoniac, I.; Bodog, A.D.; Băcilă, C.I. Chitosan-Based Biomaterials for Hemostatic Applications: A Review of Recent Advances. Int. J. Mol. Sci. 2023, 24, 10540.

Abstract

Hemorrhage is a detrimental event present in traumatic injury, surgery, and disorders of bleeding, that can become life-threatening if not properly managed. Moreover, uncontrolled bleeding can complicate surgical interventions, altering the outcome of surgical procedures. Therefore, to reduce the risk of complications and decrease the risk of morbidity and mortality associated with hemorrhage, it is necessary to use an effective hemostatic agent that ensures immediate control of bleeding. In recent years, there have been increasingly rapid advances in developing novel generation of biomaterials with hemostatic properties. Nowadays, a wide array of topical hemostatic agents is available, including chitosan-based biomaterials that have shown outstanding properties such as: antibacterial, antifungal, hemostatic, analgesic activity, in addition to their biocompatibility, biodegradability, and wound-healing effects. This review provides an analysis of chitosan-based hemostatic and discusses the progress made in their performance, mechanism of action, efficacy, cost, and safety in recent years.

Keywords

hemostasis; topical hemostatic agents; chitosan-based composites; blood-material interaction

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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