Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

In-vivo Biomechanics and Corneal Structure Alterations Induced by Acoustic Waves

Version 1 : Received: 18 May 2023 / Approved: 19 May 2023 / Online: 19 May 2023 (11:24:59 CEST)

How to cite: Ávila, F.J.; Marcellán, M.C.; Remón, L. In-vivo Biomechanics and Corneal Structure Alterations Induced by Acoustic Waves. Preprints 2023, 2023051439. https://doi.org/10.20944/preprints202305.1439.v1 Ávila, F.J.; Marcellán, M.C.; Remón, L. In-vivo Biomechanics and Corneal Structure Alterations Induced by Acoustic Waves. Preprints 2023, 2023051439. https://doi.org/10.20944/preprints202305.1439.v1

Abstract

The cornea is the optical window to the brain. Its optical and structural properties are responsible for optical transparency and vision. The shape, elasticity, rigidity or stiffness are given by its biomechanical properties, whose stability results in ocular integrity and intraocular pressure dynamics. Here, we report in vivo observation of structural changes and biomechanical alterations of the human cornea induced by acoustic wave pressure within the frequency range of 50-350 Hz and 90 dB of sound pressure level. Central corneal thickness (CCT) and eccentricity (e2) were measured using Scheimpflug imaging and biomechanical properties [corneal hysteresis (CH) and intraocular pressure (IOP] were assessed with air-puff tonometry in 6 young healthy subjects. At the specific 150 Hz acoustic frequency, the variation in CCT and e2 were of 0.058 and 7.33 µm, respectively. Biomechanical alterations were also observed in both IOP (decrease of 3.60 mmHg) and CH that showed an increase of 0.40 mmHg.

Keywords

Corneal biomechanics; corneal resonance; acoustic vibrometry

Subject

Physical Sciences, Optics and Photonics

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