Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

In Vivo Bone Progression in and around Lattice Implants Additively Manufactured with a New Titanium Alloy

Anne-Françoise Obaton
* ORCID logo ,
Jacques Fain
,
Dietmar Meinel
,
Athanasios Tsamos
ORCID logo ,
Fabien Léonard
,
Benoît Lecuelle
,
Madjid Djemaï
Version 1 : Received: 17 May 2023 / Approved: 18 May 2023 / Online: 18 May 2023 (05:43:56 CEST)

A peer-reviewed article of this Preprint also exists.

Obaton, A.-F.; Fain, J.; Meinel, D.; Tsamos, A.; Léonard, F.; Lécuelle, B.; Djemaï, M. In Vivo Bone Progression in and around Lattice Implants Additively Manufactured with a New Titanium Alloy. Appl. Sci. 2023, 13, 7282. Obaton, A.-F.; Fain, J.; Meinel, D.; Tsamos, A.; Léonard, F.; Lécuelle, B.; Djemaï, M. In Vivo Bone Progression in and around Lattice Implants Additively Manufactured with a New Titanium Alloy. Appl. Sci. 2023, 13, 7282.

Abstract

The osseointegration process in and around additively manufactured (AM) lattice structures of a new titanium alloy, Ti–19Nb–14Zr, was evaluated. Three different implants, including lattices with increasing high sidewalls gradually closing them, were designed, manufactured and implanted in the tibia and metatarsal bone of two sheep for twelve weeks. After removal, they were characterized with X-ray computed tomography (XCT). The 3D XCT images were segmented using machine learning. The bone-interface implant (BII) and bone-implant contact (BIC) were studied. The results show that, since AM naturally leads to high roughness surface finish, the wettability of the implant is increased. The new alloy possesses an increased affinity to the bone enhancing the quality of osseointegration. The lattice provides crevices, in which the biological tissue can jump in and cling. The combination of these factors is pushing ossification beyond its natural limits. Therefore, the quality and speed of the ossification and osseointegration in and around these Ti–19Nb–14Zr AM laterally closed lattice implants open the possibility of bone spline key of prostheses. This enables the stabilization of the implant into the bone while keeping the possibility of punctual hooks allowing the implant to be removed more easily if required.

Keywords

osseointegration; animal surgery; implants; lattices; titanium alloy; additive manufacturing (AM); X-ray computed tomography (XCT).

Subject

Physical Sciences, Applied Physics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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