Injectable Hydrated Calcium Phosphate Bone-Like Paste: synthesis, In Vitro and In Vivo Biocompatibility Assessment

Anastasia Yu. Teterina; Vladislav V. Minaychev; Polina V. Smirnova; Margarita I. Kobiakova; Igor V. Smirnov; Roman S. Fadeev; Alexey A. Egorov; Artem A. Ashmarin; Kira V. Pyatina; Anatoliy S. Senotov; Irina S. Fadeeva; Vladimir S. Komlev

doi:10.20944/preprints202305.1261.v1

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preprints.org > chemistry and materials science > biomaterials > doi: 10.20944/preprints202305.1261.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Injectable Hydrated Calcium Phosphate Bone-Like Paste: synthesis, In Vitro and In Vivo Biocompatibility Assessment

Anastasia Yu. Teterina

^* ,

Vladislav V. Minaychev

Polina V. Smirnova

Margarita I. Kobiakova

^* ,

Version 1 : Received: 16 May 2023 / Approved: 18 May 2023 / Online: 18 May 2023 (03:07:39 CEST)

A peer-reviewed article of this Preprint also exists.

Teterina, A.Y.; Minaychev, V.V.; Smirnova, P.V.; Kobiakova, M.I.; Smirnov, I.V.; Fadeev, R.S.; Egorov, A.A.; Ashmarin, A.A.; Pyatina, K.V.; Senotov, A.S.; Fadeeva, I.S.; Komlev, V.S. Injectable Hydrated Calcium Phosphate Bone-like Paste: Synthesis, In Vitro, and In Vivo Biocompatibility Assessment. Technologies 2023, 11, 77. Teterina, A.Y.; Minaychev, V.V.; Smirnova, P.V.; Kobiakova, M.I.; Smirnov, I.V.; Fadeev, R.S.; Egorov, A.A.; Ashmarin, A.A.; Pyatina, K.V.; Senotov, A.S.; Fadeeva, I.S.; Komlev, V.S. Injectable Hydrated Calcium Phosphate Bone-like Paste: Synthesis, In Vitro, and In Vivo Biocompatibility Assessment. Technologies 2023, 11, 77.

Abstract

The injectable hydrated calcium phosphate bone-like paste (hCPP) have been developed with suitable nanoscale characteristics and unindered injection through 23G standard needles. In vitro assays showed the cytocompatibility of hCPP with mesenchymal embryonic C3H10T1/2 cell cultures. The hCPPs were identified to be composed of aggregated nano-sized particles with sphere-like shapes with low crystallinity. The ability of serum proteins (FBS) to adsorb on hCPP particles was also studied. The hCPP demonstrated high protein adsorption capacity, thereby indicating its potential in various biomedical applications. The results of the in vivo assay upon subcutaneous injection in Wistar rats indicated the nontoxicity and biocompatibility of experimental hCPP, as well as the gradual resorption of hCPP, comparable to the period of bone regeneration. The data obtained are of great interest for the development of commercial highly effective osteoplastic materials for bone tissue regeneration and augmentation.

Keywords

biocompatible materials; calcium phosphates; hydrated pastes; bone tissue

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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