Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Role of Oxidative Stress and Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 in Nonalcoholic Fatty Liver Disease

Version 1 : Received: 16 May 2023 / Approved: 17 May 2023 / Online: 17 May 2023 (12:34:09 CEST)

A peer-reviewed article of this Preprint also exists.

Memaj, P.; Ouzerara, Z.; Jornayvaz, F.R. Role of Oxidative Stress and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2023, 24, 11271. Memaj, P.; Ouzerara, Z.; Jornayvaz, F.R. Role of Oxidative Stress and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Nonalcoholic Fatty Liver Disease. Int. J. Mol. Sci. 2023, 24, 11271.

Abstract

Nonalcoholic fatty liver disease (NAFLD) has become a widely studied subject due to its increasing prevalence and links to diseases such as type 2 diabetes and obesity. It has severe complications, including nonalcoholic steatohepatitis, cirrhosis, hepatocellular carcinoma, and portal hypertension that can lead to liver transplantation in some cases. To better prevent and treat this pathology, it is important to understand its underlying physiology. Here, we identify three main factors that play a crucial role in the physiopathology of NAFLD: oxidative stress, insulin resistance, and the key role of carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1). We discuss the pathophysiology linking these factors to NAFLD pathophysiology.

Keywords

NAFLD; NASH; insulin resistance; reactive oxygen species; CEACAM1

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

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