Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Retinal Thickness Deviation: A New Oct Parameter for Assessing Diabetic Macular Edema

Paola Marolo
* ORCID logo ,
Enrico Borrelli
,
Francesco Gelormini
,
Giacomo Boscia
ORCID logo ,
Guglielmo Parisi
ORCID logo ,
Matteo Fallico
,
Costanza Barresi
,
Giorgio Lari
,
Alessandro Berni
,
Francesco Bandello
ORCID logo ,
Michele Reibaldi
*
Version 1 : Received: 15 May 2023 / Approved: 16 May 2023 / Online: 16 May 2023 (04:43:23 CEST)

A peer-reviewed article of this Preprint also exists.

Marolo, P.; Borrelli, E.; Gelormini, F.; Boscia, G.; Parisi, G.; Fallico, M.; Barresi, C.; Lari, G.; Berni, A.; Bandello, F.; Reibaldi, M. Retinal Thickness Deviation: A New OCT Parameter for Assessing Diabetic Macular Edema. J. Clin. Med. 2023, 12, 3976. Marolo, P.; Borrelli, E.; Gelormini, F.; Boscia, G.; Parisi, G.; Fallico, M.; Barresi, C.; Lari, G.; Berni, A.; Bandello, F.; Reibaldi, M. Retinal Thickness Deviation: A New OCT Parameter for Assessing Diabetic Macular Edema. J. Clin. Med. 2023, 12, 3976.

Abstract

The purpose of the study was to determine the “retinal thickness deviation” (RTD) in diabetic macular edema (DME) eyes treated with intravitreal therapy and to establish associations be-tween RTD and best-corrected visual acuity (BCVA). We conducted a retrospective study, in-cluding consecutive DME eyes undergoing intravitreal therapy with two years of follow-up. BCVA and central subfield thickness (CST) were collected at baseline, 12 months and 24 months of follow-up. RTD was calculated as the absolute difference between measured and normative CST values at each time point. Linear regression analyses were performed between RTD and BCVA and between CST and BCVA. One hundred and four eyes were included in the analysis. The RTD was 177.0 (117.2) μm at baseline, 97.0 (99.7) μm at 12 months and 89.9 (75.3) μm at 24 months of follow-up (P < .001). RTD showed a moderate association with BCVA at baseline (R2=0.134, p<0.001) and 12 months (R2=0.197, p<0.001), and a substantial association at 24 months (R2=0.272, p<0.001). The CST showed a moderate association with BCVA at baseline (R2=0.132, p<0.001) and 12 months (R2=0.136, p<0.001), while the association was weak at 24 months (R2=0.065, p=0.009). In conclusion, RTD showed a good association with visual outcome in DME eyes undergoing intravitreal treatment.

Keywords

diabetic macular edema; diabetes; visual acuity; optical coherence tomography; macular thickness; retinal thickness; anti-VEGF; corticosteroid; deviation

Subject

Medicine and Pharmacology, Ophthalmology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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