Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Recent Insight About HE4 Role in Ovarian Cancer Oncogenesis

Emanuela Anastasi
ORCID logo ,
Antonella Farina
ORCID logo ,
Teresa Granato
,
Flavia Colaiacovo
ORCID logo ,
Beatrice Pucci
,
Sara Tartaglione
,
Antonio Angeloni
*
Version 1 : Received: 12 May 2023 / Approved: 15 May 2023 / Online: 15 May 2023 (03:19:07 CEST)

A peer-reviewed article of this Preprint also exists.

Anastasi, E.; Farina, A.; Granato, T.; Colaiacovo, F.; Pucci, B.; Tartaglione, S.; Angeloni, A. Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis. Int. J. Mol. Sci. 2023, 24, 10479. Anastasi, E.; Farina, A.; Granato, T.; Colaiacovo, F.; Pucci, B.; Tartaglione, S.; Angeloni, A. Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis. Int. J. Mol. Sci. 2023, 24, 10479.

Abstract

Currently, ovarian cancer (OC) is a target of intense biomarkers research because of its frequent late diagnosis and poor prognosis. Serum determination of Human epididymis protein 4 (HE4) is a very important early detection test. Most interestingly, HE4 plays a unique role in OC as it has been implicated not only in OC diagnosis but also in the prognosis and recurrence of this lethal neoplasm, actually acting as a clinical biomarker. There are several evidence about the predictive power of HE4 clinically, conversely less has been described concerning its role in OC oncogenesis. Based on these considerations, the main goal of this review is to clarify the role of HE4 in OC proliferation, angiogenesis, metastatization, immune response and also in the development of targeted therapy. Through a deeper understanding of its functions as a key molecule in the oncogenetic processes underlying OC, HE4 could be possibly considered as an essential resource not only for diagnosis but also for prognosis and therapy choice.

Keywords

Ovarian cancer; HE4; oncogenesis; target therapy

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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