Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Could Pulmonary Inflammation of COVID-19 ARDS Patients Worsen Due to an Excessive Repetition of Follow up Radiological Studies?

These authors contributed equally to this work.
Version 1 : Received: 9 May 2023 / Approved: 11 May 2023 / Online: 11 May 2023 (08:50:49 CEST)

A peer-reviewed article of this Preprint also exists.

Macias-Verde, D.; Lara, P.C.; Burgos-Burgos, J. Same Pollution Sources for Climate Change Might Be Hyperactivating the NLRP3 Inflammasome and Exacerbating Neuroinflammation and SARS Mortality. Medical Hypotheses 2021, 146, 110396, doi:10.1016/j.mehy.2020.110396. Macias-Verde, D.; Lara, P.C.; Burgos-Burgos, J. Same Pollution Sources for Climate Change Might Be Hyperactivating the NLRP3 Inflammasome and Exacerbating Neuroinflammation and SARS Mortality. Medical Hypotheses 2021, 146, 110396, doi:10.1016/j.mehy.2020.110396.

Abstract

United Nations Scientific Committee on the Effects of 2006 report was the first document released by an abandoned the classical paradigm that ionizing suppressive, considering the idea that at low doses enhances the appearance of antiinflammatory biomarkers [UNSCEAR 2006]. It considers energetic an immune modulation agent due to the multitude the innate immune system, depending on various age, health status, co-morbidities, genetic background, co-stressors [Lumniczky et al.]. Natural background radiation is the most hazardous public health, followed by medical imaging as a close Naturally occurring radionuclides attach to particulate ionizing radiation after inhalation and deposition in the in this article that exposure to particle radioactivity of inflammation. With that purpose, we have done an on common anti-inflammatory biomarkers between cases on COVID-19 elderly patients, and those found low-intensity natural ionizing radiation in locations with hypothesize that radioactivity increases biomarkers of strategy involved the use of databases from PubMed, (e.g., dose response, hormesis, J-shaped, NLRP3 LNT model, etc.). Extrapolating these effects to artificial ionizing radiation drawn conclusions on the over use of X-ray computed images in elderly ICU admitted patients with pulmonary oxygen species (ROS) generation by this action seems inflammation of leucine-rich protein 3 (NLRP3) inflammasome, waking up an over cytokine production.

Keywords

Acute Respiratory Distress Syndrome; COVID-19; Computed Tomography; Hormesis; Ionizing radiation; NLRP3 inflammasome

Subject

Medicine and Pharmacology, Immunology and Allergy

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