Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Unlocking the Secrets of Androgen Receptors in the Susceptibility, Progression, and Treatment of Prostate Cancer

Version 1 : Received: 10 May 2023 / Approved: 10 May 2023 / Online: 10 May 2023 (09:09:13 CEST)
Version 2 : Received: 23 September 2023 / Approved: 25 September 2023 / Online: 25 September 2023 (16:46:10 CEST)

How to cite: Zakari, S.; Ekenwaneze, C.C.; Amadi, E.C.; Ogunlana, O.O. Unlocking the Secrets of Androgen Receptors in the Susceptibility, Progression, and Treatment of Prostate Cancer. Preprints 2023, 2023050720. https://doi.org/10.20944/preprints202305.0720.v1 Zakari, S.; Ekenwaneze, C.C.; Amadi, E.C.; Ogunlana, O.O. Unlocking the Secrets of Androgen Receptors in the Susceptibility, Progression, and Treatment of Prostate Cancer. Preprints 2023, 2023050720. https://doi.org/10.20944/preprints202305.0720.v1

Abstract

Prostate cancer (PCa) is a significant cause of cancer-related deaths globally, with an increasing incidence over the years. Our review article aims to unlock the secrets of androgen receptors in prostate cancer susceptibility, progression, and treatment by analyzing recent literature. Androgen receptor (AR) plays a crucial role in male development and maintains masculine characteristics. However, in prostate cancer, AR signaling pathway aberrations can lead to disease progression and treatment resistance. Understanding AR regulation and function in healthy and diseased states is essential for developing effective treatment strategies to combat this disease and improve patient outcomes. Our findings have significant implications for developing new treatments and identifying biomarkers for early detection and personalized treatment targeting the AR signalling pathway.

Keywords

Prostate cancer; androgen receptor; AR signaling pathway; disease progression; therapeutic re-sistance; personalized treatment; androgen deprivation therapy; AR-targeted therapies

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

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