Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated With Haemophilus influenzae Meningitis in a Newborn

Noely E. Ferreira
,
Antonio Charlys Da Costa
ORCID logo ,
Esper Kallas
,
Cassia G.T. Silveira
,
Ana Carolina Soares
,
Layla Honorato
ORCID logo ,
Heuder Gustavo Oliveira Paiao
,
Silvia Helena Lima
,
Dewton M. Vasconcelos
,
Marina F. Côrtes
,
Silvia Figueiredo Costa
,
Tania Regina Tozetto-Mendoza
,
Hélio Rodrigues Gomes
,
Steven S. Witkin
,
Maria Cassia Mendes-Correa
* ORCID logo
Version 1 : Received: 8 May 2023 / Approved: 9 May 2023 / Online: 9 May 2023 (08:41:09 CEST)

How to cite: Ferreira, N. E.; Da Costa, A. C.; Kallas, E.; Silveira, C. G.; Soares, A. C.; Honorato, L.; Paiao, H. G. O.; Lima, S. H.; Vasconcelos, D. M.; Côrtes, M. F.; Costa, S. F.; Tozetto-Mendoza, T. R.; Gomes, H. R.; Witkin, S. S.; Mendes-Correa, M. C. Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated With Haemophilus influenzae Meningitis in a Newborn. Preprints 2023, 2023050609. https://doi.org/10.20944/preprints202305.0609.v1 Ferreira, N. E.; Da Costa, A. C.; Kallas, E.; Silveira, C. G.; Soares, A. C.; Honorato, L.; Paiao, H. G. O.; Lima, S. H.; Vasconcelos, D. M.; Côrtes, M. F.; Costa, S. F.; Tozetto-Mendoza, T. R.; Gomes, H. R.; Witkin, S. S.; Mendes-Correa, M. C. Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated With Haemophilus influenzae Meningitis in a Newborn. Preprints 2023, 2023050609. https://doi.org/10.20944/preprints202305.0609.v1

Abstract

Parvovirus B19 infection is associated with a wide range of clinical manifestations, from asymp-tomatic to severe neurological disorders. Its major clinical symptoms, fever and rash, are com-mon to multiple viruses, and laboratory tests to detect B19 are frequently not available. Thus, the impact of B19 on public health remains unclear. We report the case of a 38-day old girl ad-mitted to São Paulo Clinical Hospital, Brazil, with an initial diagnosis of bacterial meningitis, seizures, and acute hydrocephalus. Antibiotic therapy was maintained for one week after admis-sion and discontinued after negative laboratory results were obtained. Nine days after symp-toms onset, a cerebral spinal fluid (CSF) sample revealed persistent pleocytosis. The complete B19 complete genome was subsequently identified in her CSF by a metagenomic next-generation sequencing approach. This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations, and emphasizes that its possible involve-ment might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.

Keywords

Human parvovirus B19; Encephalopathy; Metagenomic next-generation sequencing.

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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