Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated With Haemophilus influenzae Meningitis in a Newborn

Version 1 : Received: 8 May 2023 / Approved: 9 May 2023 / Online: 9 May 2023 (08:41:09 CEST)

How to cite: Ferreira, N.E.; Da Costa, A.C.; Kallas, E.; Silveira, C.G.; Soares, A.C.; Honorato, L.; Paiao, H.G.O.; Lima, S.H.; Vasconcelos, D.M.; Côrtes, M.F.; Costa, S.F.; Tozetto-Mendoza, T.R.; Gomes, H.R.; Witkin, S.S.; Mendes-Correa, M.C. Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated With Haemophilus influenzae Meningitis in a Newborn. Preprints 2023, 2023050609. https://doi.org/10.20944/preprints202305.0609.v1 Ferreira, N.E.; Da Costa, A.C.; Kallas, E.; Silveira, C.G.; Soares, A.C.; Honorato, L.; Paiao, H.G.O.; Lima, S.H.; Vasconcelos, D.M.; Côrtes, M.F.; Costa, S.F.; Tozetto-Mendoza, T.R.; Gomes, H.R.; Witkin, S.S.; Mendes-Correa, M.C. Encephalopathy Caused by Human Parvovirus B19 Genotype 1 Associated With Haemophilus influenzae Meningitis in a Newborn. Preprints 2023, 2023050609. https://doi.org/10.20944/preprints202305.0609.v1

Abstract

Parvovirus B19 infection is associated with a wide range of clinical manifestations, from asymp-tomatic to severe neurological disorders. Its major clinical symptoms, fever and rash, are com-mon to multiple viruses, and laboratory tests to detect B19 are frequently not available. Thus, the impact of B19 on public health remains unclear. We report the case of a 38-day old girl ad-mitted to São Paulo Clinical Hospital, Brazil, with an initial diagnosis of bacterial meningitis, seizures, and acute hydrocephalus. Antibiotic therapy was maintained for one week after admis-sion and discontinued after negative laboratory results were obtained. Nine days after symp-toms onset, a cerebral spinal fluid (CSF) sample revealed persistent pleocytosis. The complete B19 complete genome was subsequently identified in her CSF by a metagenomic next-generation sequencing approach. This report highlights the possible involvement of B19 in the occurrence of acute neurological manifestations, and emphasizes that its possible involve-ment might be better revealed by the use of metagenomic technology to detect viral agents in clinical situations of unknown or uncertain etiology.

Keywords

Human parvovirus B19; Encephalopathy; Metagenomic next-generation sequencing.

Subject

Biology and Life Sciences, Virology

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