Raslan, M.A.; Raslan, S.A.; Shehata, E.M.; Mahmoud, A.S.; Lundstrom, K.; Barh, D.; Azevedo, V.; Sabri, N.A. Associations between Nutrigenomic Effects and Incidences of Microbial Resistance against Novel Antibiotics. Pharmaceuticals2023, 16, 1093.
Raslan, M.A.; Raslan, S.A.; Shehata, E.M.; Mahmoud, A.S.; Lundstrom, K.; Barh, D.; Azevedo, V.; Sabri, N.A. Associations between Nutrigenomic Effects and Incidences of Microbial Resistance against Novel Antibiotics. Pharmaceuticals 2023, 16, 1093.
Raslan, M.A.; Raslan, S.A.; Shehata, E.M.; Mahmoud, A.S.; Lundstrom, K.; Barh, D.; Azevedo, V.; Sabri, N.A. Associations between Nutrigenomic Effects and Incidences of Microbial Resistance against Novel Antibiotics. Pharmaceuticals2023, 16, 1093.
Raslan, M.A.; Raslan, S.A.; Shehata, E.M.; Mahmoud, A.S.; Lundstrom, K.; Barh, D.; Azevedo, V.; Sabri, N.A. Associations between Nutrigenomic Effects and Incidences of Microbial Resistance against Novel Antibiotics. Pharmaceuticals 2023, 16, 1093.
Abstract
Nutrigenomics is the study of the interaction of nutrition and genes, focusing on the influence of nutrients on the genome, proteome, and metabolome, and how nutrition affects human health. In the context of nutrigenomics, bioactive components are dietary ingredients that may transmit information from the external environment and alter gene expression in the cell, and hence the overall function of the organism. It is critical to consider food not only as a source of energy and essential nutrients necessary for life and growth, but also as a factor impacting health/disease, biochemical processes, biochemical pathway activation and affecting the diversity of the gut microbiome. Antimicrobial resistance in pathogenic and commensal microorganisms has emerged as a major public health concern due to emerging antimicrobial resistance genes in E. coli isolates from pig, cattle, chicken, and turkey meat, against tetracycline, streptomycin, and sulfonamides. Also, Salmonella spp. and Campylobacter spp. have shown antibiotic resistance at farms and slaughterhouses, and in animal-based food products. A correlation has been proven between a critical nutrient-responsive signaling system and catabolite control of gene expression, and a two-component signaling system that drives antibiotic resistance in E. faecalis, revealing a previously unknown integration between the nutritional status of the cell and intrinsic antibiotic resistance. Moreover, different nutrigenomic approaches can be applied to mitigate possible emergence of antimicrobial resistance against novel antibiotics. However, little progress has been achieved in converting nutrigenomics information into clinical advice, so far.
Keywords
Nutrigenomics; Antimicrobial resistance; Novel Antibiotics; gut microbiome
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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