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Role of SNAREs and Rabs in Myelin Regulation
Version 1
: Received: 5 May 2023 / Approved: 5 May 2023 / Online: 5 May 2023 (13:44:10 CEST)
A peer-reviewed article of this Preprint also exists.
Margiotta, A. Role of SNAREs and Rabs in Myelin Regulation. Int. J. Mol. Sci. 2023, 24, 9772. Margiotta, A. Role of SNAREs and Rabs in Myelin Regulation. Int. J. Mol. Sci. 2023, 24, 9772.
Abstract
The nervous system is composed of neurons, which conduct the signals, and glial cells that provide metabolic and functional support and protection to neurons. An important component of the nervous system is the myelin sheath, an insulating layer around the nerves of the brain and spinal cord, which allows a fast and efficient nerve conduction and therefore the proper transmission of signal to all tissues and organs. Myelin is made of protein and fatty substances and gives protection for the propagation of the electrical impulse. Myelin alterations determine the onset of several neuropathies as the electrical signal can be slowed or stopped. Myelin is formed by oligodendrocytes in the central nervous system (CNS) and by Schwann cells in the peripheral nervous system (PNS). Differences in myelination in the CNS and PNS have been found and molecules involved in membrane trafficking such as SNAREs and rabs have been proved to contribute to several aspects regarding the formation of myelin or dysmyelination. Here, I will describe the role of these proteins in regulating membrane trafficking and nerve conduction, myelin biogenesis and maintenance.
Keywords
SNAREs; Rabs; neurotransmitter release; myelin
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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