Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Molecular Mechanisms and Risk Factors Related to Pathogenesis of Peyronie's Disease

Yozo Mitsui
* ORCID logo ,
Fumito Yamabe
,
Shunsuke Hori
,
Masato Uetani
,
Hideyuki Kobayashi
ORCID logo ,
Koichi Nagao
,
Koichi Nakajima
Version 1 : Received: 29 April 2023 / Approved: 30 April 2023 / Online: 30 April 2023 (02:21:49 CEST)

A peer-reviewed article of this Preprint also exists.

Mitsui, Y.; Yamabe, F.; Hori, S.; Uetani, M.; Kobayashi, H.; Nagao, K.; Nakajima, K. Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease. Int. J. Mol. Sci. 2023, 24, 10133. Mitsui, Y.; Yamabe, F.; Hori, S.; Uetani, M.; Kobayashi, H.; Nagao, K.; Nakajima, K. Molecular Mechanisms and Risk Factors Related to the Pathogenesis of Peyronie’s Disease. Int. J. Mol. Sci. 2023, 24, 10133.

Abstract

Peyronie's disease (PD) is a benign condition caused by plaque formation on the tunica albuginea of the penis. It is associated with penile pain, curvature, and shortening, and contributes to erectile dysfunction, which worsens patient quality of life. In recent years, understanding of the detailed mechanisms and risk factors involved in development of PD has been increasing. In this review, the pathological mechanisms and several closely related signaling pathways, including TGF-β, WNT/β-catenin, Hedgehog, YAP/TAZ, MAPK, ROCK, and PI3K/AKT, are described. Findings regarding cross-talk among these pathways are then discussed to elucidate the complicated cascade behind tunica albuginea fibrosis. Finally, various risk factors including genetic involved in the development of PD are presented and their association with the disease summarized. The purpose of this review is to provide better understanding regarding involvement of risk factors in the molecular mechanisms associated with PD pathogenesis, as well as provide insight into disease prevention and novel therapeutic interventions.

Keywords

Peyronie's disease; pathogenesis; risk factors; molecular mechanisms, transforming growth factor-β1

Subject

Medicine and Pharmacology, Urology and Nephrology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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