Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Molecular Mechanisms Driven by MT4-MMP in Cancer Progression

Emma Muñoz-Sáez
ORCID logo ,
Natalia Moracho
,
Ana I. R. Learte
,
Alice Collingnon
ORCID logo ,
Alicia G. Arroyo
ORCID logo ,
Agnés Noel
,
Nor Eddine Sounni
* ORCID logo ,
Cristina Sánchez-Camacho
* ORCID logo
Version 1 : Received: 26 April 2023 / Approved: 26 April 2023 / Online: 26 April 2023 (11:19:22 CEST)

A peer-reviewed article of this Preprint also exists.

Muñoz-Sáez, E.; Moracho, N.; Learte, A.I.R.; Collignon, A.; Arroyo, A.G.; Noel, A.; Sounni, N.E.; Sánchez-Camacho, C. Molecular Mechanisms Driven by MT4-MMP in Cancer Progression. Int. J. Mol. Sci. 2023, 24, 9944. Muñoz-Sáez, E.; Moracho, N.; Learte, A.I.R.; Collignon, A.; Arroyo, A.G.; Noel, A.; Sounni, N.E.; Sánchez-Camacho, C. Molecular Mechanisms Driven by MT4-MMP in Cancer Progression. Int. J. Mol. Sci. 2023, 24, 9944.

Abstract

MT4-MMP (or MMP-17) belongs to the Membrane-Type Matrix Metalloproteinases (MT-MMPs), a distinct subset of the MMP family that is anchored to the cell surface by a glycosylphosphatidylinositol (GPI) motif. Its expression in a variety of cancers is well documented. However, the molecular mechanisms by which MT4-MMP contributes to tumor development need further investigation. In this review, we aim to summarize the contribution of MT4-MMP in tumorigenesis, focusing on the molecular mechanisms triggered by the enzyme in tumor cell migration, invasiveness, and proliferation, in the tumor vasculature and microenvironment, as well as during metastasis. In particular, we highlight the putative substrates processed and signaling cascades activated by MT4-MMP that may underlie these malignancy processes and compare this with what is known about its role during embryonic development. Finally, MT4-MMP is a relevant biomarker of malignancy that can be used for monitoring cancer diseases progression in patients as well as a potential target for future therapeutic drug development.

Keywords

MT4-MMP; MMP-17; development; vasculature; tumor; cancer cell; malignancy; therapy; bi-omarker

Subject

Biology and Life Sciences, Cell and Developmental Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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