Version 1
: Received: 22 April 2023 / Approved: 23 April 2023 / Online: 23 April 2023 (13:45:23 CEST)
How to cite:
Karpów-Greiner, M.; Komisarek, O.; Sekielska, M.; Knypiński, W.; Adamczak, R.; Dubiel, M. Associations between Maternal Serum Biomarkers and Uterine Artery and Ductus Venosus Blood Flow Patterns in Early Pregnancy Doppler Ultrasound Study. Preprints2023, 2023040803. https://doi.org/10.20944/preprints202304.0803.v1
Karpów-Greiner, M.; Komisarek, O.; Sekielska, M.; Knypiński, W.; Adamczak, R.; Dubiel, M. Associations between Maternal Serum Biomarkers and Uterine Artery and Ductus Venosus Blood Flow Patterns in Early Pregnancy Doppler Ultrasound Study. Preprints 2023, 2023040803. https://doi.org/10.20944/preprints202304.0803.v1
Karpów-Greiner, M.; Komisarek, O.; Sekielska, M.; Knypiński, W.; Adamczak, R.; Dubiel, M. Associations between Maternal Serum Biomarkers and Uterine Artery and Ductus Venosus Blood Flow Patterns in Early Pregnancy Doppler Ultrasound Study. Preprints2023, 2023040803. https://doi.org/10.20944/preprints202304.0803.v1
APA Style
Karpów-Greiner, M., Komisarek, O., Sekielska, M., Knypiński, W., Adamczak, R., & Dubiel, M. (2023). Associations between Maternal Serum Biomarkers and Uterine Artery and Ductus Venosus Blood Flow Patterns in Early Pregnancy Doppler Ultrasound Study. Preprints. https://doi.org/10.20944/preprints202304.0803.v1
Chicago/Turabian Style
Karpów-Greiner, M., Rafał Adamczak and Mariusz Dubiel. 2023 "Associations between Maternal Serum Biomarkers and Uterine Artery and Ductus Venosus Blood Flow Patterns in Early Pregnancy Doppler Ultrasound Study" Preprints. https://doi.org/10.20944/preprints202304.0803.v1
Abstract
Background: In this study, we aimed to evaluate the effect of s-FLT-1 and PlGF concentrations in women in the first trimester of pregnancy on the pulsatility index of the ductus venosus and the right and left uterine arteries. Methods: A total of 108 pregnant women in their first trimester were included in the study, with 87 assigned to the experimental group and 21 to the control group. Ultrasound examination were performed to measure the uterine artery pulsatility index, resistance index, ductus venosus pulsatility index, and blood sampling levels of biomarkers such as b-HCG; PAPP-A; s-FLT-1 and PlGF. Results: There was a significant negative relationship between PAPP-A concentration and the risk of fetal growth restriction, and a significant negative relationship between PlGF concentration and the risk of preeclampsia and fetal growth restriction in women in their first trimester of pregnancy. There was also a significant positive relationship between sFLT-1/PLGF ratio and the risk of developing preeclampsia. No significant relationships were found between the concentrations of biomarkers beta-HCG, PAPP-A, sFLT-1, PlGF, and any of the parameters PIUARt, PIUALt, Mean uterine arteries, and DVPI. Summary: In conclusion, this study did not find conclusive evidence to support the hypothesis that beta-HCG, PAPP-A, s-FLT-1, and PlGF concentrations in women in the first trimester of pregnancy have a significant effect on the Pulsatility Index of the ductus venosus and the Right and left Uterine Arteries. Further research is needed to investigate these potential associations.
Keywords
b-HCG; PAPP-A; s-FLT-1; PlGF; pulsatility index of the ductus venosus; pulsatility index of the right and left uterine arteries
Subject
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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