Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Review on Additives in Hydrogels for 3D Bioprinting of Regenerative Medicine: From Mechanism to Methodology

Version 1 : Received: 20 April 2023 / Approved: 20 April 2023 / Online: 20 April 2023 (08:00:19 CEST)

A peer-reviewed article of this Preprint also exists.

Fang, W.; Yang, M.; Liu, M.; Jin, Y.; Wang, Y.; Yang, R.; Wang, Y.; Zhang, K.; Fu, Q. Review on Additives in Hydrogels for 3D Bioprinting of Regenerative Medicine: From Mechanism to Methodology. Pharmaceutics 2023, 15, 1700. Fang, W.; Yang, M.; Liu, M.; Jin, Y.; Wang, Y.; Yang, R.; Wang, Y.; Zhang, K.; Fu, Q. Review on Additives in Hydrogels for 3D Bioprinting of Regenerative Medicine: From Mechanism to Methodology. Pharmaceutics 2023, 15, 1700.

Abstract

Regeneration of biological tissues in medicine is challenging, and 3D bioprinting offers an innovative way to create functional multicellular tissues. One common way in bioprinting is bioink which is one type of the cell-loaded hydrogel. For clinical application, however, the bioprinting still suffers from satisfactory performance, e.g. in vascularization, effective antibacterial, immunomodulation and regulation of collagen deposition. Many studies have incorporated different bioactive materials into the 3D printed scaffolds to optimize the bioprinting. Here, we review a variety of additives added to the 3D bioprinting hydrogel. The underlying mechanisms and methodology for biological regeneration are important and will provide useful basis for future research.

Keywords

3D bioprinting; hydrogel; bioink; tissue engineering; bionic scaffold

Subject

Medicine and Pharmacology, Medicine and Pharmacology

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