Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Gut Microbial Metabolite Butyrate and its Therapeutic Role in Inflammatory Bowel Disease

Version 1 : Received: 17 April 2023 / Approved: 18 April 2023 / Online: 18 April 2023 (07:36:05 CEST)

A peer-reviewed article of this Preprint also exists.

Recharla, N.; Geesala, R.; Shi, X.-Z. Gut Microbial Metabolite Butyrate and Its Therapeutic Role in Inflammatory Bowel Disease: A Literature Review. Nutrients 2023, 15, 2275. Recharla, N.; Geesala, R.; Shi, X.-Z. Gut Microbial Metabolite Butyrate and Its Therapeutic Role in Inflammatory Bowel Disease: A Literature Review. Nutrients 2023, 15, 2275.

Abstract

Intestinal commensal microbes, called the gut microbiota, play a critical role in host immune homeostasis through active microbial metabolites and innate and adaptive immune responses. Dysbiosis or imbalance of the gut microbiota composition is associated with inflammatory bowel disease (IBD) which includes Crohn’s disease and ulcerative colitis. The incidence and prevalence rates of IBD have been increasing worldwide. It is well recognized that butyrate, a microbial metabolite of diet fibers, is a major energy source for colonocytes and plays a crucial role in regulating immune function and maintaining epithelial barrier function and intestinal homeostasis. Emerging evidence suggests that butyrate might be a potential therapeutic agent to treat IBD. In this review, we discuss about gut microbial metabolites, particularly butyrate, the synthesis and metabolism of butyrate, mechanisms of butyrate in immune and epithelial barrier function. Furthermore, we review the current research on various therapeutic implications of butyrate in IBD.

Keywords

butyrate; inflammatory bowel disease; gut microbiota; microbial metabolites; nutrients; gut homeostasis; immune responses; T-cells

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

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