Villena-Salinas, J.; Ortega-Lozano, S.J.; Amrani-Raissouni, T.; Agüera, E.; Caballero-Villarraso, J. Diagnostic Effectiveness of [123I]Ioflupane Single Photon Emission Computed Tomography (SPECT) in Multiple System Atrophy. J. Clin. Med.2023, 12, 3478.
Villena-Salinas, J.; Ortega-Lozano, S.J.; Amrani-Raissouni, T.; Agüera, E.; Caballero-Villarraso, J. Diagnostic Effectiveness of [123I]Ioflupane Single Photon Emission Computed Tomography (SPECT) in Multiple System Atrophy. J. Clin. Med. 2023, 12, 3478.
Villena-Salinas, J.; Ortega-Lozano, S.J.; Amrani-Raissouni, T.; Agüera, E.; Caballero-Villarraso, J. Diagnostic Effectiveness of [123I]Ioflupane Single Photon Emission Computed Tomography (SPECT) in Multiple System Atrophy. J. Clin. Med.2023, 12, 3478.
Villena-Salinas, J.; Ortega-Lozano, S.J.; Amrani-Raissouni, T.; Agüera, E.; Caballero-Villarraso, J. Diagnostic Effectiveness of [123I]Ioflupane Single Photon Emission Computed Tomography (SPECT) in Multiple System Atrophy. J. Clin. Med. 2023, 12, 3478.
Abstract
Background: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder that has no curative treatment. Diagnosis is based on a set of criteria established by Gilman (1998 and 2008) and recently updated by Wenning (2022). We aim to determine the effectiveness of [123I]Ioflupane SPECT in MSA, especially at the initial clinical suspicion. Methods: Cross-sectional study of patients at initial clinical suspicion of MSA, referred for [123I]Ioflupane SPECT. Results: 139 patients (68 men, 71 women) were included, 104 being MSA-probable and 35 MSA-possible. MRI was normal in 89.2% while SPECT was positive in 78.45%. SPECT showed high sensitivity (82.46%) and positive predictive value (86.24), reaching maximum sensitivity in MSA-P (97.26%). Significant differences were found when relating both SPECT assessments in the healthy-sick and inconclusive-sick groups. We also found an association when relating SPECT to the subtype (MSA-C or MSA-P), as well as to the presence of parkinsonian symptoms. Lateralization of striatal involvement was detected (left side). Conclusions: [123I]Ioflupane SPECT is a useful and reliable tool for diagnosing MSA, with good effectiveness and accuracy. Qualitative assessment shows a clear superiority when distinguishing between the healthy-sick categories, as well as between the parkinsonian (MSA-P) and cerebellar (MSA-C) subtypes at initial clinical suspicion.
Keywords
multiple system atrophy; dysautonomia; functional neuroimaging testing; diagnostic accuracy; Ioflupane-123; cross-sectional study
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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