Version 1
: Received: 14 April 2023 / Approved: 14 April 2023 / Online: 14 April 2023 (08:45:15 CEST)
How to cite:
Vu, H.T.; Nguyen, V.D.; Matsubara, T. Roles of PPARα and PPARγ As Regulator of Free Fatty Acids in Nonalcoholic Steatohepatitis. Preprints2023, 2023040356. https://doi.org/10.20944/preprints202304.0356.v1
Vu, H.T.; Nguyen, V.D.; Matsubara, T. Roles of PPARα and PPARγ As Regulator of Free Fatty Acids in Nonalcoholic Steatohepatitis. Preprints 2023, 2023040356. https://doi.org/10.20944/preprints202304.0356.v1
Vu, H.T.; Nguyen, V.D.; Matsubara, T. Roles of PPARα and PPARγ As Regulator of Free Fatty Acids in Nonalcoholic Steatohepatitis. Preprints2023, 2023040356. https://doi.org/10.20944/preprints202304.0356.v1
APA Style
Vu, H.T., Nguyen, V.D., & Matsubara, T. (2023). Roles of PPARα and PPARγ As Regulator of Free Fatty Acids in Nonalcoholic Steatohepatitis. Preprints. https://doi.org/10.20944/preprints202304.0356.v1
Chicago/Turabian Style
Vu, H.T., Vien Duc Nguyen and Tsutomu Matsubara. 2023 "Roles of PPARα and PPARγ As Regulator of Free Fatty Acids in Nonalcoholic Steatohepatitis" Preprints. https://doi.org/10.20944/preprints202304.0356.v1
Abstract
In recent years, nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) has become a leading worldwide disease, and its therapies are facing many complexities. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear receptor (NR) superfamily and have three subtypes: PPARα (NR1C1), PPARβ/δ (NR1C2), and PPARγ (NR1C3). They have been identified to be essential in the regulation of lipid metabolism by controlling the transcription of genes related to fatty acids, bile acids, and cholesterol metabolism. Many PPAR agonists have been reported, such as natural agonists (fatty acids, eicosanoids, and phospholipids) and synthetic ligands (fibrates, thiazolidinediones, glitazars, and elafibranor). PPAR-based chemicals have a breakthrough in the innovation of therapy for fatty liver disease. This review will provide an overview of how PPARα and PPARγ play roles in lipid homeostasis, discussing the consideration of their agonists as potential therapeutic agents for NAFLD/NASH.
Keywords
PPAR; NAFLD; NASH
Subject
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
