Version 1
: Received: 31 March 2023 / Approved: 11 April 2023 / Online: 11 April 2023 (10:14:48 CEST)
How to cite:
Waidha, K.; Aftab, M.; Singh, D.; Hussain, S. Role of Phytochemicals and their Derivatives in Targeting Stem Cell Markers in Breast and Cervical Cancer. Preprints2023, 2023040220. https://doi.org/10.20944/preprints202304.0220.v1
Waidha, K.; Aftab, M.; Singh, D.; Hussain, S. Role of Phytochemicals and their Derivatives in Targeting Stem Cell Markers in Breast and Cervical Cancer. Preprints 2023, 2023040220. https://doi.org/10.20944/preprints202304.0220.v1
Waidha, K.; Aftab, M.; Singh, D.; Hussain, S. Role of Phytochemicals and their Derivatives in Targeting Stem Cell Markers in Breast and Cervical Cancer. Preprints2023, 2023040220. https://doi.org/10.20944/preprints202304.0220.v1
APA Style
Waidha, K., Aftab, M., Singh, D., & Hussain, S. (2023). Role of Phytochemicals and their Derivatives in Targeting Stem Cell Markers in Breast and Cervical Cancer. Preprints. https://doi.org/10.20944/preprints202304.0220.v1
Chicago/Turabian Style
Waidha, K., Divyam Singh and Showket Hussain. 2023 "Role of Phytochemicals and their Derivatives in Targeting Stem Cell Markers in Breast and Cervical Cancer" Preprints. https://doi.org/10.20944/preprints202304.0220.v1
Abstract
Breast and Cervical cancer are significant causes of morbidity and mortality among women worldwide. Usually, conventional therapies and early detection has shown success in metastasis and relapse rates and improved overall survival of the patients. The elimination of the efficacy of chemotherapies and target therapies because cancer stem cells create resistance against chemotherapy, metastasis, and relapse. Studies reveal that cancer stem cell markers are important for improving efficiencies of targeted therapies. Our study aims to analyze the stem cell markers and target the most significant stem cell marker by phytochemicals and their derivates. Through the analysis, it was observed that CXCR4 and SOX-2, mir-1, mir-125, and mir-429 may have a crucial role in stemness of breast and cervical cancer respectively, while BPMD & MD simulations revealed Di-valinoyl curcumin as a potential compound for CXCR4 targeting.
Keywords
breast cancer; cervical cancer; stem cells; docking; simulation; microRNA
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
