Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

SUMOtherapeutics for Ischemic Stroke

Paramesh Karandikar
ORCID logo ,
Jakob Gerstl
ORCID logo ,
Ari Kappel
,
Sae-Yeon Won
,
Daniel Dubinski
,
Monica Emili Garcia-Segura
,
Florian Gessler
,
Alfred Pokmeng See
,
Luca Peruzzotti Jametti
ORCID logo ,
Joshua Bernstock
*
Version 1 : Received: 4 April 2023 / Approved: 6 April 2023 / Online: 6 April 2023 (12:21:33 CEST)

A peer-reviewed article of this Preprint also exists.

Karandikar, P.; Gerstl, J.V.E.; Kappel, A.D.; Won, S.-Y.; Dubinski, D.; Garcia-Segura, M.E.; Gessler, F.A.; See, A.P.; Peruzzotti-Jametti, L.; Bernstock, J.D. SUMOtherapeutics for Ischemic Stroke. Pharmaceuticals 2023, 16, 673. Karandikar, P.; Gerstl, J.V.E.; Kappel, A.D.; Won, S.-Y.; Dubinski, D.; Garcia-Segura, M.E.; Gessler, F.A.; See, A.P.; Peruzzotti-Jametti, L.; Bernstock, J.D. SUMOtherapeutics for Ischemic Stroke. Pharmaceuticals 2023, 16, 673.

Abstract

Small, Ubiquitin-like Modifier (SUMO) is a post-translational modifier with a profound influence on several key biological processes including the mammalian stress response. Of particular interest is its neuroprotective effects, first recognized in the 13-lined ground squirrel (Ictidomys tridecemlineatus), in the context of hibernation torpor. Although the full scope of the SUMO pathway is yet to be elucidated, observations of its importance in managing neuronal responses to ischemia, maintaining ion gradients, and preconditioning of neural stem cells, make it a promising therapeutic target for acute cerebral ischemia. Recent advances in high-throughput screening have enabled the identification of small molecules that can upregulate SUMOylation, some of which have been validated in pertinent preclinical models of cerebral ischemia. Accordingly, the present review aims to summarize current knowledge and highlight the translational potential of the SUMOylation pathway in brain ischemia.

Keywords

stroke; ischemia; neuroprotection; SUMOylation; experimental therapeutics

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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