Version 1
: Received: 29 March 2023 / Approved: 30 March 2023 / Online: 30 March 2023 (03:30:16 CEST)
How to cite:
Wang, X.; Elbahrawi, R.; Abdukadir, A.M.; Ali, Z.M.; Corridon, P. A Proposed Model of Xeno-Keratoplasty Using 3D Printing and Decellularization. Preprints2023, 2023030522. https://doi.org/10.20944/preprints202303.0522.v1
Wang, X.; Elbahrawi, R.; Abdukadir, A.M.; Ali, Z.M.; Corridon, P. A Proposed Model of Xeno-Keratoplasty Using 3D Printing and Decellularization. Preprints 2023, 2023030522. https://doi.org/10.20944/preprints202303.0522.v1
Wang, X.; Elbahrawi, R.; Abdukadir, A.M.; Ali, Z.M.; Corridon, P. A Proposed Model of Xeno-Keratoplasty Using 3D Printing and Decellularization. Preprints2023, 2023030522. https://doi.org/10.20944/preprints202303.0522.v1
APA Style
Wang, X., Elbahrawi, R., Abdukadir, A.M., Ali, Z.M., & Corridon, P. (2023). A Proposed Model of Xeno-Keratoplasty Using 3D Printing and Decellularization. Preprints. https://doi.org/10.20944/preprints202303.0522.v1
Chicago/Turabian Style
Wang, X., Zehara Mohammed Ali and Peter Corridon. 2023 "A Proposed Model of Xeno-Keratoplasty Using 3D Printing and Decellularization" Preprints. https://doi.org/10.20944/preprints202303.0522.v1
Abstract
Corneal opacity is a leading cause of vision impairment and suffering worldwide. Transplantation can effectively restore vision and reduce chronic discomfort. However, there is a considerable shortage of viable corneal graft tissues. Tissue engineering may address this issue by advancing xeno- keratoplasty as a viable alternative to conventional keratoplasty. In particular, livestock decellularization strategies offer the potential to generate bioartificial ocular prosthetics in sufficient supply to match existing and projected needs. To this end, we have examined the best practices and characterizations that have supported the current state-of-the-art driving preclinical and clinical applications. Identifying the challenges that delimit activities to supplement the donor corneal pool derived from acellular scaffolds allowed us to hypothesize a model for keratoprosthesis applications derived from livestock combining 3D printing and decellularization.
Keywords
cornea; xeno-keratoplasty; decellularization; recellularization; 3D bioprinting; slaughterhouse waste
Subject
Medicine and Pharmacology, Ophthalmology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
