Tassone, A.; Meringolo, M.; Ponterio, G.; Bonsi, P.; Schirinzi, T.; Martella, G. Mitochondrial Bioenergy in Neurodegenerative Disease: Huntington and Parkinson. Int. J. Mol. Sci.2023, 24, 7221.
Tassone, A.; Meringolo, M.; Ponterio, G.; Bonsi, P.; Schirinzi, T.; Martella, G. Mitochondrial Bioenergy in Neurodegenerative Disease: Huntington and Parkinson. Int. J. Mol. Sci. 2023, 24, 7221.
Tassone, A.; Meringolo, M.; Ponterio, G.; Bonsi, P.; Schirinzi, T.; Martella, G. Mitochondrial Bioenergy in Neurodegenerative Disease: Huntington and Parkinson. Int. J. Mol. Sci.2023, 24, 7221.
Tassone, A.; Meringolo, M.; Ponterio, G.; Bonsi, P.; Schirinzi, T.; Martella, G. Mitochondrial Bioenergy in Neurodegenerative Disease: Huntington and Parkinson. Int. J. Mol. Sci. 2023, 24, 7221.
Abstract
Much evidence suggests a correlation between degeneration and mitochondrial impairment. Typical cases of degeneration can also be observed in physiological phenomena (aging) as well as in neurological neurodegenerative diseases and cancer. All these pathologies have as a common denominator the dyshomeostasis of mitochondrial bioenergy. Even neurodegenerative diseases show a bioenergetics imbalance in their pathogenesis or progression. Huntington's chorea and Parkinson's disease are both neurodegenerative diseases, but while Huntington's disease is a genetic, and progressive disease with early manifestation and severe penetrance, Parkinson's disease is a pathology with a multifactorial aspect. Indeed, there are different types of Parkinson/Parkinsonism. Many forms are early onset diseases linked to gene mutation, others can appear in young adults and senescent only post-injury, and a final group is idiopathic. Huntington's was defined as a hyperkinetic disorder, while Parkinson's is a hypokinetic disorder; but in the middle, there are a lot of similarities as well as neuronal excitability, the loss of striatal function, psychiatric comorbidity, etc. In the review, we would embrace the theories that both diseases start and develop in light of mitochondrial dysfunction. These dysfunctions act on energy metabolism and reduce the vitality of neurons in many different brain areas.
Keywords
movement disorders; mitochondria; energy metabolism; synaptic plasticity; basal ganglia; calcium
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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