Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Enhanced Solid-State Fluorescence of Flavin Derivatives by In-Corporation in the Metal-Organic Frameworks MIL-53(Al) and MOF-5

Version 1 : Received: 27 February 2023 / Approved: 28 February 2023 / Online: 28 February 2023 (03:06:40 CET)

A peer-reviewed article of this Preprint also exists.

Püschel, D.; Hédé, S.; Maisuls, I.; Höfert, S.-P.; Woschko, D.; Kühnemuth, R.; Felekyan, S.; Seidel, C.A.M.; Czekelius, C.; Weingart, O.; Strassert, C.A.; Janiak, C. Enhanced Solid-State Fluorescence of Flavin Derivatives by Incorporation in the Metal-Organic Frameworks MIL-53(Al) and MOF-5. Molecules 2023, 28, 2877. Püschel, D.; Hédé, S.; Maisuls, I.; Höfert, S.-P.; Woschko, D.; Kühnemuth, R.; Felekyan, S.; Seidel, C.A.M.; Czekelius, C.; Weingart, O.; Strassert, C.A.; Janiak, C. Enhanced Solid-State Fluorescence of Flavin Derivatives by Incorporation in the Metal-Organic Frameworks MIL-53(Al) and MOF-5. Molecules 2023, 28, 2877.

Abstract

The flavin derivatives 10‐methyl‐isoalloxazine (MIA) and 6-fluoro-10-methyl-isoalloxazine (6F-MIA) were encapsulated in two alternative metal-organic frameworks, (MOFs) MIL53(Al) and MOF5, using a post-synthetic, diffusion-based incorporation into microcrystalline MIL-53 powders and an in-situ approach during the MOF-5 synthesis. The flavin@MOF composites were analyzed by powder X-ray diffractometry (PXRD), N2-sorption studies and time-resolved fluorescence spectroscopy and microscopy. The maximum amount of flavin dye incorporation is 3.9 wt% for MIA@MIL-53(Al) and 1.5 wt% for 6F-MIA@MIL-53(Al), 0.85 wt% for MIA@MOF-5 and 27.6 wt% for 6F-MIA@MOF-5. The emission wavelengths of all flavin@MOF composites mostly correspond to the wavelengths of the flavins in solution. Time-resolved spectroscopy showed that the fluorescence lifetime of flavin@MOF of 2-4.7 ns also corresponds to those in solution but is significantly prolonged compared to the solid flavin dyes with less than 1 ns, thereby confirming the concept of "solid solutions" for dye@MOF composites. The fluorescence quantum yield (ΦF) of the flavin@MOF composites is about half of the solution but is significantly higher compared to the solid flavin dyes. Both the fluorescence lifetime and quantum yield of flavin@MOF decrease with the flavin loading in MIL-53. Theoretical calculations using plane-wave and QM/MM methods are in good correspondence with the experimental results and explain the electronic structures as well as the photoluminescence/photophysical properties of crystalline MIA and the flavin@MOF composites. In the solids flavins π-stacking interactions of the molecules lead to a charge transfer state with low oscillator strength resulting in aggregation-caused quenching (ACQ) with low lifetimes and quantum yields. In the MOF pores the flavin molecules are separated and the computed MIA@MOF structures do not find π-stacking interactions to the pore walls but only weak van-der-Waals contacts which reasons the enhanced fluorescence lifetime and quantum yield of the flavins in the composites compared to their neat solid state. The flexible MOF MIL-53(Al) was optimized essentially to the experimental large-pore form in the guest-free state with QuantumEspresso (QE) and with MIA molecules in the pores the structure contracted to close to the experimental narrow-pore form which was also confirmed by PXRD. In summary, the incorporation of flavins in MOFs yields solid-state materials with enhanced rigidity, stabilized conformation and reduced aggregations of the flavins, leading to increased fluorescence lifetime and quantum yield as controllable photo-luminescent and photo-physical properties.

Keywords

flavins; 10‐methyl‐isoalloxazine; metal-organic framework (MOF); MIL-53; MOF-5; fluorescence; flavin@MOF; solid solution

Subject

Chemistry and Materials Science, Physical Chemistry

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