Sun, C.-h.; Hou, J.-h.; Sun, S.-y.; Zhang, Y.; Zhang, X.-r.; Mu, L.-t. Green Separation and Extraction of Isofraxidin from Acanthopanax senticosus Using Deep Eutectic Solvent Synthesized from Choline Chloride and Citric Acid. Processes 2023, 11, 943. https://doi.org/10.3390/pr11030943
Sun, C.-h.; Hou, J.-h.; Sun, S.-y.; Zhang, Y.; Zhang, X.-r.; Mu, L.-t. Green Separation and Extraction of Isofraxidin from Acanthopanax senticosus Using Deep Eutectic Solvent Synthesized from Choline Chloride and Citric Acid. Processes 2023, 11, 943. https://doi.org/10.3390/pr11030943
Sun, C.-h.; Hou, J.-h.; Sun, S.-y.; Zhang, Y.; Zhang, X.-r.; Mu, L.-t. Green Separation and Extraction of Isofraxidin from Acanthopanax senticosus Using Deep Eutectic Solvent Synthesized from Choline Chloride and Citric Acid. Processes 2023, 11, 943. https://doi.org/10.3390/pr11030943
Sun, C.-h.; Hou, J.-h.; Sun, S.-y.; Zhang, Y.; Zhang, X.-r.; Mu, L.-t. Green Separation and Extraction of Isofraxidin from Acanthopanax senticosus Using Deep Eutectic Solvent Synthesized from Choline Chloride and Citric Acid. Processes 2023, 11, 943. https://doi.org/10.3390/pr11030943
Abstract
Acanthopanax senticosus(rupr. rt. Maxim.; AS) is a medicinal plant used in the clinical treatment of cerebrovascular diseases and central nervous system disorders, significantly improving blood lipid levels and endothelial cell function in patients with acute cerebral infarction. Isofraxidin, one of the active ingredients of AS, is the core of the medical effects, and its extraction and purification depend on organic solvents. Deep eutectic solvents (DESs) is a new green solvent, synthesized by intermolecular hydrogen bonding between hydrogen bond donors (HBD) and hydrogen bond acceptors (HBA), which has non-toxic, high separation and purification efficiency, and environmentally friendly compared with traditional organic solvents. In this paper, DES was used for the extraction of isofraxidin from AS. The primary findings demonstrate that the DESs had a viscosity higher than that of ethanol, and even adding a tiny amount of water (about 10%) would trigger solvent redistribution, leading to a considerable reduction in solvent viscosity. In comparison to ethanol, the extraction rate of isofraxidin by DESs was 2-3 times higher. Thus, this work developed a new technique for using green extraction of isofraxidin that has some practical implications.
Keywords
Acanthopanax senticosus; Deep eutectic solvents; Isofraxidin; Extraction
Subject
Chemistry and Materials Science, Analytical Chemistry
Copyright:
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