Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

COVID-19 and Vasa Vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings

Version 1 : Received: 14 February 2023 / Approved: 16 February 2023 / Online: 16 February 2023 (02:18:09 CET)

A peer-reviewed article of this Preprint also exists.

Macarova, J.A.; Malakhova, S.A.; Novitskaya, T.A.; Shapkina, V.A.; Churilov, L.P. COVID-19 and Vasa vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings. Diagnostics 2023, 13, 1097. Macarova, J.A.; Malakhova, S.A.; Novitskaya, T.A.; Shapkina, V.A.; Churilov, L.P. COVID-19 and Vasa vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings. Diagnostics 2023, 13, 1097.

Abstract

Patients with COVID-19 demonstrate higher rates of cardiovascular complications, including thromboses and thromboembolism. One may suppose that the action of SARS-CoV-2 transforms stable atherosclerotic plaques into unstable status. Cardiovascular complications in COVID-19 may be caused by progressive viral alteration the blood vessels, including vasa vasorum. A lethal case of ischemic brain disease caused by cerebral atherosclerosis and exacerbated with a stroke during COVID-19 infection is briefly described. The results of autopsy showed perivascular lymphocytic infiltration and signs of vasa vasorum vasculitis with thrombi of adventitial microvasculature. The data discussed in the article are interpreted in context of the concept giving the important role in atherogenesis to vasa vasorum.

Keywords

COVID-19; SARS-CoV-2; atherosclerosis

Subject

Medicine and Pharmacology, Pathology and Pathobiology

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