Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Vaginal Microbiota Transplantation: Possible Mechanisms and Future Perspectives

Version 1 : Received: 13 February 2023 / Approved: 14 February 2023 / Online: 14 February 2023 (09:23:33 CET)

How to cite: Tuniyazi, M.; Li, S.; Fu, Y.; Hu, X.; Zhang, N. Vaginal Microbiota Transplantation: Possible Mechanisms and Future Perspectives. Preprints 2023, 2023020242. https://doi.org/10.20944/preprints202302.0242.v1 Tuniyazi, M.; Li, S.; Fu, Y.; Hu, X.; Zhang, N. Vaginal Microbiota Transplantation: Possible Mechanisms and Future Perspectives. Preprints 2023, 2023020242. https://doi.org/10.20944/preprints202302.0242.v1

Abstract

The human body is inhabited by unique microbial communities that protect and regulate the host against pathogens and inflammation. To address issues related to disrupted microbial composition, microbial transfer therapy (MTT) has emerged as a potential treatment option. The most popular form of MTT is fecal microbiota transplantation (FMT), which has been successful in treating various diseases. Another emerging form of MTT is vaginal microbiota transplantation (VMT), transferring of the vaginal microbiota from a healthy female donor to a diseased patient's vaginal cavity, which aims to restore normal vaginal microbial composition. However, VMT is vastly unexplored due to safety concerns and lack of research. This paper explores the mechanisms involved in VMT's therapeutic effect and discusses future perspectives. Further research is needed to advance VMT's clinical applications and techniques.

Keywords

vaginal microbiota transplantation; dysbiosis; treatment; mechanism

Subject

Medicine and Pharmacology, Transplantation

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