Masson, H.O.; Karottki, K.J. la C.; Tat, J.; Hefzi, H.; Lewis, N.E. From Observational to Actionable: Rethinking Omics in Biologics Production. Trends in Biotechnology 2023, doi:10.1016/j.tibtech.2023.03.009.
Masson, H.O.; Karottki, K.J. la C.; Tat, J.; Hefzi, H.; Lewis, N.E. From Observational to Actionable: Rethinking Omics in Biologics Production. Trends in Biotechnology 2023, doi:10.1016/j.tibtech.2023.03.009.
Cite as:
Masson, H.O.; Karottki, K.J. la C.; Tat, J.; Hefzi, H.; Lewis, N.E. From Observational to Actionable: Rethinking Omics in Biologics Production. Trends in Biotechnology 2023, doi:10.1016/j.tibtech.2023.03.009.
Masson, H.O.; Karottki, K.J. la C.; Tat, J.; Hefzi, H.; Lewis, N.E. From Observational to Actionable: Rethinking Omics in Biologics Production. Trends in Biotechnology 2023, doi:10.1016/j.tibtech.2023.03.009.
Abstract
As the era of omics continues to expand, omics-based experiments have become popular in industrial biotechnology. They promise deeper biological understanding, which may be leveraged to develop novel solutions to bioprocess optimization and cell line engineering strategies. Despite this expansion, naivety about what omic data offers and how to best handle such data can challenge the extraction of actionable value. However, the value of omic experiments in biotechnology research and development can be maximized with deliberate application of omic approaches and forethought about analysis techniques. Here we describe important considerations when designing and implementing omic-based experiments, and discuss how systems biology analysis strategies can enhance efforts to obtain actionable insights in biomanufacturing.
Keywords
biopharmaceutical protein production; cell line development; bioprocess optimization; omics; statistical inference; mechanistic models
Subject
Engineering, Bioengineering
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
