Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Risk Factors for Mortality of Adult Patients With COVID-19: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico

Carlos Axel López Pérez
ORCID logo ,
Francisco Javier Santa Cruz Pavlovich
ORCID logo ,
Juan Eduardo Montiel Cortés
,
Adriana Nuñez Muratalla
,
Ruth Bibani Morán González
,
Ricardo Villanueva Gaona
ORCID logo ,
Xochitl Franco Mojica
,
Denisse Gabriela Moreno Sandoval
ORCID logo ,
Joselyn Anacaren González Bañuelos
ORCID logo ,
Alan Ulises López Pérez
,
Marily Flores González
ORCID logo ,
Cristina Grijalva Ruiz
,
Edna Daniela Valdez Mendoza
ORCID logo ,
Luis Renee González Lucano
,
Martín López Zendejas
*
Version 1 : Received: 20 January 2023 / Approved: 24 January 2023 / Online: 24 January 2023 (13:21:09 CET)

A peer-reviewed article of this Preprint also exists.

López-Pérez, C.A.; Santa Cruz-Pavlovich, F.J.; Montiel-Cortés, J.E.; Núñez-Muratalla, A.; Morán-González, R.B.; Villanueva-Gaona, R.; Franco-Mojica, X.; Moreno-Sandoval, D.G.; González-Bañuelos, J.A.; López-Pérez, A.U.; Flores-González, M.; Grijalva-Ruiz, C.; Valdez-Mendoza, E.D.; González-Lucano, L.R.; López-Zendejas, M. Risk Factors for Mortality of Hospitalized Adult Patients with COVID-19 Pneumonia: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico. Int. J. Environ. Res. Public Health 2023, 20, 4450. López-Pérez, C.A.; Santa Cruz-Pavlovich, F.J.; Montiel-Cortés, J.E.; Núñez-Muratalla, A.; Morán-González, R.B.; Villanueva-Gaona, R.; Franco-Mojica, X.; Moreno-Sandoval, D.G.; González-Bañuelos, J.A.; López-Pérez, A.U.; Flores-González, M.; Grijalva-Ruiz, C.; Valdez-Mendoza, E.D.; González-Lucano, L.R.; López-Zendejas, M. Risk Factors for Mortality of Hospitalized Adult Patients with COVID-19 Pneumonia: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico. Int. J. Environ. Res. Public Health 2023, 20, 4450.

Abstract

During the COVID-19 pandemic, the high prevalence of comorbidities in Mexico, as well as the disparities between public and private health subsystems, substantially contributed to the severe impact it had in the country. The objective of this study was to evaluate and compare risk factors present at admission for mortality of hospitalized patients with COVID-19. A 2-year retrospective cohort study of hospitalized adult patients with COVID-19 was conducted at a private tertiary care center. The study population consisted of 1,258 patients with a median age of 56 ± 16.5 years, of whom 1,093 recovered (86.8%) and 165 died (13.1%). In the univariate analysis, older age (p <0.001), comorbidities such as hypertension (p <0.001) and diabetes (p <0.001), signs and symptoms of respiratory distress, and markers of acute inflammatory response were significantly more frequent in non-survivors. The multivariate analysis showed that older age (p <0.001), the presence of cyanosis (p 0.005) and previous myocardial infarction (p 0.032) were independent predictors for mortality. In the studied cohort, risk factors present at admission associated with an increased risk of death were older age, cyanosis and a previous myocardial infarction, which can be used as valuable predictors for patients’ outcomes. To our knowledge, this is the first study analyzing predictors of mortality in COVID-19 patients attended on a private tertiary hospital in Mexico.

Keywords

COVID-19; Cohort; Mortality; Mexico

Subject

Public Health and Healthcare, Public Health and Health Services

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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