Exploring the Biological Properties of Zn(II) Bisthiosemicarbazone Helicates

Sandra Fernández-Fariña; Isabel Velo-Heleno; Rocío Carballido; Miguel Martínez-Calvo; Ramiro Barcia; Òscar Palacios; Mercè Capdevila; Ana M. González-Noya; Rosa Pedrido

doi:10.20944/preprints202212.0544.v1

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preprints.org > chemistry and materials science > inorganic and nuclear chemistry > doi: 10.20944/preprints202212.0544.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Exploring the Biological Properties of Zn(II) Bisthiosemicarbazone Helicates

Sandra Fernández-Fariña

^* ,

Isabel Velo-Heleno

Rocío Carballido

Miguel Martínez-Calvo

^* ,

Version 1 : Received: 22 December 2022 / Approved: 28 December 2022 / Online: 28 December 2022 (12:45:04 CET)

A peer-reviewed article of this Preprint also exists.

Fernández-Fariña, S.; Velo-Heleno, I.; Carballido, R.; Martínez-Calvo, M.; Barcia, R.; Palacios, Ò.; Capdevila, M.; González-Noya, A.M.; Pedrido, R. Exploring the Biological Properties of Zn(II) Bisthiosemicarbazone Helicates. Int. J. Mol. Sci. 2023, 24, 2246. Fernández-Fariña, S.; Velo-Heleno, I.; Carballido, R.; Martínez-Calvo, M.; Barcia, R.; Palacios, Ò.; Capdevila, M.; González-Noya, A.M.; Pedrido, R. Exploring the Biological Properties of Zn(II) Bisthiosemicarbazone Helicates. Int. J. Mol. Sci. 2023, 24, 2246.

Abstract

The design of artificial helicoidal molecules derived from metal ions with biological properties is one of the objectives within Metallosupramolecular Chemistry. Herein, we report three zinc helicates derived from a family of bisthiosemicarbazone ligands with different terminal groups, Zn2(LMe)2∙2H2O 1, Zn2(LPh)2∙2H2O 2 and Zn2(LPhNO2)2 3, obtained by an electrochemical methodology. These helicates have been fully characterized by different techniques, including X-Ray diffraction. Biological studies of the zinc(II) helicates such as toxicity assays with erythrocytes and interaction studies with proteins and oligonucleotides were performed, demonstrating in all cases low toxicity and an absence of covalent interaction with the proteins and oligonucleotides. The in vitro cytotoxicity of the helicates was tested against MCF-7 (human breast carcinoma), A2780 (human ovarian carcinoma cells), NCI-H460 (human lung carcinoma cells) and MRC-5 (normal lung human fibroblast), comparing the IC50 values with cisplatin. We will try to demonstrate if the terminal substituent of the ligand precursor exerts any effect in toxicity or in the antitumor activity of the zinc helicates.

Keywords

bisthiosemicarbazone ligands; zinc; helicates; biological activity.

Subject

Chemistry and Materials Science, Inorganic and Nuclear Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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