Core -Shell Particles: from Fabrication Methods to Diverse Manipulation Techniques

Ajeet Singh Yadav; Du Tuan Tran; Adrian J. T. Teo; Yuchen Dai; Fariba Malekpour Galogahi; Nam-Trung Nguyen; Chin Hong Ooi

doi:10.20944/preprints202212.0463.v1

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preprints.org > medicine and pharmacology > pharmacy > doi: 10.20944/preprints202212.0463.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Core -Shell Particles: from Fabrication Methods to Diverse Manipulation Techniques

Fariba Malekpour Galogahi

Nam-Trung Nguyen

^* ,

Chin Hong Ooi

Version 1 : Received: 19 December 2022 / Approved: 26 December 2022 / Online: 26 December 2022 (02:51:41 CET)

A peer-reviewed article of this Preprint also exists.

Yadav, A.S.; Tran, D.T.; Teo, A.J.T.; Dai, Y.; Galogahi, F.M.; Ooi, C.H.; Nguyen, N.-T. Core–Shell Particles: From Fabrication Methods to Diverse Manipulation Techniques. Micromachines 2023, 14, 497. Yadav, A.S.; Tran, D.T.; Teo, A.J.T.; Dai, Y.; Galogahi, F.M.; Ooi, C.H.; Nguyen, N.-T. Core–Shell Particles: From Fabrication Methods to Diverse Manipulation Techniques. Micromachines 2023, 14, 497.

Abstract

Core-shell particles are heterogenous micro- or nanoparticles with solid, liquid or gas core encapsulated by a protective solid shell. The unique composition of core and shell materials imparts smart properties to the particles. Core-shell particles are gaining increasing attention as tuneable and versatile carriers for pharmaceutical and biomedical applications including targeted drug delivery, controlled drug release, and biosensing. This review first provides an overview of fabrication methods for core-shell particles, followed by a brief discussion on their application and a detailed analysis on manipulation including assembly, sorting, and triggered release. We compile current methodologies employed for manipulation of core-shell particles and demonstrate how existing methods of assembly and sorting micro/nanospheres can be adopted or modified for core-shell particles. Various triggered release approaches for diagnostics and drug delivery are also discussed in detail.

Keywords

Core shell particles; digital microfluidics

Subject

Medicine and Pharmacology, Pharmacy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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