Saint-Pierre Contreras, G.; Conei Valencia, D.; Lizama, L.; Vargas Zuñiga, D.; Avendaño Carvajal, L.F.; Ampuero Llanos, S. An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat? Viruses2023, 15, 330.
Saint-Pierre Contreras, G.; Conei Valencia, D.; Lizama, L.; Vargas Zuñiga, D.; Avendaño Carvajal, L.F.; Ampuero Llanos, S. An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat? Viruses 2023, 15, 330.
Saint-Pierre Contreras, G.; Conei Valencia, D.; Lizama, L.; Vargas Zuñiga, D.; Avendaño Carvajal, L.F.; Ampuero Llanos, S. An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat? Viruses2023, 15, 330.
Saint-Pierre Contreras, G.; Conei Valencia, D.; Lizama, L.; Vargas Zuñiga, D.; Avendaño Carvajal, L.F.; Ampuero Llanos, S. An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat? Viruses 2023, 15, 330.
Abstract
Human adenoviruses are one of the most important pathogens detected in acute respiratory diseases in pediatrics and immunocompromised patients. In 1953, Wallace Rowe described it for the first time in oropharyngeal lymphatic tissue. To date, more than 85 types of HAdV have been described, with different cellular tropisms. They can cause respiratory and gastrointestinal symptoms, even urinary tract inflammation, although most infections are asymptomatic. However, there is a population at risk that can develop serious and even lethal conditions. These viruses have a double-stranded DNA genome, 25-48 kbp, 90 nm in diameter, without a mantle, stable in the environment, and resistant to fat-soluble detergents. Currently the diagnosis is made with lateral flow immunochromatography or molecular biology through a polymerase chain reaction. The objective of this review is to recognize the variability of HAdV, the pandemic potential that a recombinant could present between HAdV-3 and 7 viral types, known to produce aggressive outbreaks in health facilities. The review determined the characteristics of HAdV, from the infection to treatment, vaccine development and the evaluation of the social determinants of health associated with HAdV, guiding the necessary measures for future sanitary control, and preventing disasters such as the SARS-CoV-2 pandemic.
Keywords
Infections; Human Adenovirus; Social Determinants of Health; Adenovirus Vaccine; Genotype; Molecular Diagnostic Testing
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
