Version 1
: Received: 1 December 2022 / Approved: 21 December 2022 / Online: 21 December 2022 (03:53:32 CET)
Version 2
: Received: 24 January 2023 / Approved: 25 January 2023 / Online: 25 January 2023 (04:43:01 CET)
Tintoré, M.; Cuñé, J.; Vetvicka, V.; de Lecea, C. Anti-Inflammatory Effects, Protection of Gut Barrier Integrity and Stimulation of Phagocytosis of Postbiotic Combination ABB C1. Nutraceuticals2023, 3, 109-118.
Tintoré, M.; Cuñé, J.; Vetvicka, V.; de Lecea, C. Anti-Inflammatory Effects, Protection of Gut Barrier Integrity and Stimulation of Phagocytosis of Postbiotic Combination ABB C1. Nutraceuticals 2023, 3, 109-118.
Tintoré, M.; Cuñé, J.; Vetvicka, V.; de Lecea, C. Anti-Inflammatory Effects, Protection of Gut Barrier Integrity and Stimulation of Phagocytosis of Postbiotic Combination ABB C1. Nutraceuticals2023, 3, 109-118.
Tintoré, M.; Cuñé, J.; Vetvicka, V.; de Lecea, C. Anti-Inflammatory Effects, Protection of Gut Barrier Integrity and Stimulation of Phagocytosis of Postbiotic Combination ABB C1. Nutraceuticals 2023, 3, 109-118.
Abstract
This study evaluated the anti-inflammatory effects, protection of gut barrier integrity, and stimulation of phagocytosis in peripheral cells of a nutritional supplement based on a synergistic combination of yeast-based ingredients with a unique 1,3/1,6-glucan complex and a consortium of postbiotic Saccharomyces cerevisiae rich in selenium and zinc. The anti-inflammatory effect in Caco-2 cells in the presence and absence of a pro-inflammatory challenge (tumour necrosis factor alpha [TNF-α]/interferon gamma [IFN-ɣ]) showed statistically significant reductions of IFN-ɣ induced protein-10 (IP-10), and monocyte chemoattractant protein-1 (MCP-1) levels vs. controls (p < 0.001). Disruption of the gut integrity in the presence or absence of Escherichia coli (ETEC H10407) showed transepithelial electrical resistance (TEER) values higher in the ABB C1® group after 6 hours of testing. Spontaneous build-up of the gut epithelium monolayer over 22 days was also greater in the ABB C1® condition vs. a negative control. ABB C1® showed a significantly higher capacity to stimulate phagocytosis as compared with controls of algae β-1,3-glucan and yeast β-1,3/1,6 glucan (p < 0.001). This study supports the mechanism of action by which ABB C1® may improve the immune response and be useful to prevent infection and allergy in clinical practice.
Keywords
Saccharomyces cerevisiae; beta-glucans; selenium; zinc; gut barrier; modulation; COVID-19; nutritional supplementation; allergy; inflammatory process
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
25 January 2023
Commenter:
Maria Tintoré
Commenter's Conflict of Interests:
Author
Comment:
Following the suggestions received during the peer-review process, we have shortened the article title, imporved the quality and homogenized the aspect of the figures and provided additional background and references in the introduction and discussion sections.
Commenter: Maria Tintoré
Commenter's Conflict of Interests: Author