Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The RNA-binding Protein SMN as a Novel Player in Laryngeal Squamous Cell Carcinoma

Francesca Gabanella
,
Andrea Colizza
ORCID logo ,
Maria Chiara Mottola
,
Silvia Francati
,
Giovanna Blaconà
,
Carla Petrella
ORCID logo ,
Christian Barbato
ORCID logo ,
Antonio Greco
ORCID logo ,
Massimo Ralli
ORCID logo ,
Marco Fiore
,
Nicoletta Corbi
,
Giampiero Ferraguti
ORCID logo ,
Alessandro Corsi
ORCID logo ,
Antonio Minni
,
Marco De Vincentiis
,
Claudio Passananti
,
Maria Grazia Di Certo
*
Version 1 : Received: 17 December 2022 / Approved: 19 December 2022 / Online: 19 December 2022 (09:02:58 CET)

A peer-reviewed article of this Preprint also exists.

Gabanella, F.; Colizza, A.; Mottola, M.C.; Francati, S.; Blaconà, G.; Petrella, C.; Barbato, C.; Greco, A.; Ralli, M.; Fiore, M.; Corbi, N.; Ferraguti, G.; Corsi, A.; Minni, A.; de Vincentiis, M.; Passananti, C.; Di Certo, M.G. The RNA-Binding Protein SMN as a Novel Player in Laryngeal Squamous Cell Carcinoma. Int. J. Mol. Sci. 2023, 24, 1794. Gabanella, F.; Colizza, A.; Mottola, M.C.; Francati, S.; Blaconà, G.; Petrella, C.; Barbato, C.; Greco, A.; Ralli, M.; Fiore, M.; Corbi, N.; Ferraguti, G.; Corsi, A.; Minni, A.; de Vincentiis, M.; Passananti, C.; Di Certo, M.G. The RNA-Binding Protein SMN as a Novel Player in Laryngeal Squamous Cell Carcinoma. Int. J. Mol. Sci. 2023, 24, 1794.

Abstract

Head and neck squamous cell carcinoma (HNSCC) arise from the mucosal epithelium in the oral cavity, pharynx, sino-nasal region, and larynx. Laryngeal squamous cell carcinoma (LSCC) represents one-third of all head and neck cancers. Dysregulated RNA-related pathways define an important molecular signature in this aggressive carcinoma. The Survival Motor Neuron (SMN) protein regulates fundamental aspects of the RNA metabolism but, curiously, its role in cancer is virtually unknown. For the first time, here we focus on SMN in cancer context. We conducted a pilot study in a total of 20 patients with LSCC where SMN was found overexpressed at both the protein and transcript levels. By a cellular model of human laryngeal carcinoma, we demonstrated that SMN impacts cancer-relevant behaviors and perturbs key players of cell migration, invasion, and adhesion. Furthermore, in LSCC we showed a physical interaction between SMN and the epidermal growth factor receptor (EGFR), whose overexpression is an important feature in these tumours. This study candidates SMN as novel therapeutic target in LSSC, and likely in the whole spectrum of HNSCC. Overall, we provide the first analysis of SMN in human cancer.

Keywords

SMN; RNA-binding proteins; head and neck cancers; squamous cell carcinoma; EGFR

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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